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Skeletal Radiology
Published in: Skeletal Radiology 11/2015

01-11-2015 | Case Report

Soft-tissue aneurysmal bone cyst with translocation t(17;17)(p13;q21) corresponding to COL1A1 and USP6 loci

Authors: Cyril Jacquot, Jadwiga Szymanska, Lakshmi J. Nemana, Lynne S. Steinbach, Andrew E. Horvai

Published in: Skeletal Radiology | Issue 11/2015

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Abstract

We present the case of a 46-year-old woman with no significant past medical history who developed left mid-thigh pain and fullness. Imaging demonstrated a mineralized soft-tissue mass, which increased in size during a year of monitoring, but retained a circumscribed appearance. The mass was located in the medial soft tissues of the thigh, separate from the bone on imaging studies, and this finding was confirmed during excision. The mass showed gross and microscopic features of an aneurysmal bone cyst. This diagnosis was supported by cytogenetic analysis revealing a t(17;17)(p13;q21) translocation corresponding to the USP6 and COL1A1 loci. Soft-tissue aneurysmal bone cyst is a rare entity, with fewer than 25 reports in the literature. Limited cytogenetic information about these tumors is available. To our knowledge, the USP6 and COL1A1 rearrangement has only previously been described in a pediatric soft-tissue aneurysmal bone cyst. We also discuss the differential diagnosis of ossifying soft-tissue lesions.
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Metadata
Title
Soft-tissue aneurysmal bone cyst with translocation t(17;17)(p13;q21) corresponding to COL1A1 and USP6 loci
Authors
Cyril Jacquot
Jadwiga Szymanska
Lakshmi J. Nemana
Lynne S. Steinbach
Andrew E. Horvai
Publication date
01-11-2015
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 11/2015
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-015-2205-6

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