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BMC Cancer
Published in: BMC Cancer 1/2014

Open Access 01-12-2014 | Review

Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

Authors: Salvatore Micali, Stefania Bulotta, Cinzia Puppin, Angelo Territo, Michele Navarra, Giampaolo Bianchi, Giuseppe Damante, Sebastiano Filetti, Diego Russo

Published in: BMC Cancer | Issue 1/2014

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Abstract

Background

Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia. Discovery of NIS expression in extrathyroidal tissues, including transformed cells, has opened a novel field of research regarding NIS-expressing extrathyroidal neoplasia. Indeed, expression of NIS may be used as a biomarker for diagnostic, prognostic, and therapeutic purposes. Moreover, stimulation of endogenous NIS expression may permit the radioiodine treatment of extrathyroidal lesions by concentrating this radioisotope.

Results

This review describes recent findings in NIS research in extrathyroidal malignancies, focusing on breast and urological cancer, emphasizing the most relevant developments that may have clinical impact.

Conclusions

Given the recent progress in the study of NIS regulation as molecular basis for new therapeutic approaches in extrathyroidal cancers, particular attention is given to studies regarding the relationship between NIS and clinical-pathological aspects of the tumors and the regulation of NIS expression in the experimental models.
Appendix
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Metadata
Title
Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer
Authors
Salvatore Micali
Stefania Bulotta
Cinzia Puppin
Angelo Territo
Michele Navarra
Giampaolo Bianchi
Giuseppe Damante
Sebastiano Filetti
Diego Russo
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-14-303

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