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01-01-2018 | Original Article

Sodium fluoride does not affect the working memory and number of pyramidal cells in rat medial prefrontal cortex

Authors: Zulhaini Sartika A. Pulungan, Zaenal Muttaqien Sofro, Ginus Partadiredja

Published in: Anatomical Science International | Issue 1/2018

Abstract

Fluoride is a chemical compound known to bring about fluorosis. It is thought to disrupt the central nervous system because of its ability to induce excitotoxicity and oxidative stress. Any damage of pyramidal cells in the prefrontal cortex would result in cognitive function and working memory regulation disorders. The present study aimed at investigating the effects of sodium fluoride (NaF) on the working memory and estimated total number of medial prefrontal cortex pyramidal cells of adult male rats. Thirty-two male Wistar rats were assigned into four groups, namely control and three treated groups receiving 5, 10 and 20 mg/kg BW, respectively, of oral NaF solution for 30 days. The working memory test was carried out using a Y-maze. The number of pyramidal cells in the medial prefrontal cortex was estimated using an unbiased stereological method. There was no significant difference among groups in the working memory and number of pyramidal neurons in the medial prefrontal cortex cells.

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Title: Sodium fluoride does not affect the working memory and number of pyramidal cells in rat medial prefrontal cortex
Authors: Zulhaini Sartika A. Pulungan
Zaenal Muttaqien Sofro
Ginus Partadiredja
Publication date: 01-01-2018
Publisher: Springer Japan
Published in: Anatomical Science International / Issue 1/2018
Print ISSN: 1447-6959
Electronic ISSN: 1447-073X
DOI: https://doi.org/10.1007/s12565-016-0384-4

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