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01-12-2013 | Psychiatry and Preclinical Psychiatric Studies - Original Article

Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain

Authors: Samira S. Valvassori, Karen V. Calixto, Josiane Budni, Wilson R. Resende, Roger B. Varela, Karolina V. de Freitas, Cinara L. Gonçalves, Emilio L. Streck, João Quevedo

Published in: Journal of Neural Transmission | Issue 12/2013

Abstract

There is increasing interest in the possibility that mitochondrial impairment may play an important role in bipolar disorder (BD). The Krebs cycle is the central point of oxidative metabolism, providing carbon for biosynthesis and reducing agents for generation of ATP. Recently, studies have suggested that histone deacetylase (HDAC) inhibitors may have antimanic effects. The present study aims to investigate the effects of sodium butyrate (SB), a HDAC inhibitor, on Krebs cycle enzymes activity in the brain of rats subjected to an animal model of mania induced by d-amphetamine (d-AMPH). Wistar rats were first given d-AMPH or saline (Sal) for 14 days, and then, between days 8 and 14, rats were treated with SB or Sal. The citrate synthase (CS), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) were evaluated in the prefrontal cortex, hippocampus, and striatum of rats. The d-AMPH administration inhibited Krebs cycle enzymes activity in all analyzed brain structures and SB reversed d-AMPH-induced dysfunction analyzed in all brain regions. These findings suggest that Krebs cycle enzymes’ inhibition can be an important link for the mitochondrial dysfunction seen in BD and SB exerts protective effects against the d-AMPH-induced Krebs cycle enzymes’ dysfunction.

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Title: Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain
Authors: Samira S. Valvassori
Karen V. Calixto
Josiane Budni
Wilson R. Resende
Roger B. Varela
Karolina V. de Freitas
Cinara L. Gonçalves
Emilio L. Streck
João Quevedo
Publication date: 01-12-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 12/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1056-3

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Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain

Abstract

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Springer Medicine

Abstract

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