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01-03-2010 | Poster presentation

Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice

Authors: M Okajima, M Takamura, S Usui, T Taniguchi, S Kaneko

Published in: Critical Care | Special Issue 1/2010

Excerpt

Unfolded protein response (UPR)-mediated apoptosis plays a pivotal role in ischemia-reperfusion injury. Sodium 4-phenylbutyrate (PBA) has been reported to act as a chemical chaperone inhibiting UPR-mediated apoptosis triggered by ischemia in various organs other than the heart. Therefore we investigated whether PBA reduces UPR-mediated apoptosis and protects against myocardial ischemia-reperfusion injury in mice. …

Qi X, et al.: Mol Pharmacol. 2004, 66: 899-908. 10.1124/mol.104.001339CrossRef

Vilatoba M: Surgery. 2005, 138: 342-351. 10.1016/j.surg.2005.04.019CrossRef

Title: Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice
Authors: M Okajima
M Takamura
S Usui
T Taniguchi
S Kaneko
Publication date: 01-03-2010
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 1/2010
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc8234

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Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice

Excerpt

Keynote webinar | Spotlight on medication adherence

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Excerpt

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