Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Public Health
Published in: BMC Public Health 1/2018

Open Access 01-12-2018 | Research article

Social determinants of prostate cancer in the Caribbean: a systematic review and meta-analysis

Authors: Catherine R. Brown, Ian Hambleton, Shawn M. Hercules, Nigel Unwin, Madhuvanti M. Murphy, E. Nigel Harris, Rainford Wilks, Marlene MacLeish, Louis Sullivan, Natasha Sobers-Grannum, The U.S. Caribbean Alliance for Health Disparities Research Group (USCAHDR)

Published in: BMC Public Health | Issue 1/2018

Login to get access

Abstract

Background

Prostate cancer remains the leading cause of cancer deaths among Caribbean men. However, little data exists on the influence of social factors on prostate cancer in the Caribbean setting. This article supports the 2011 Rio Political Declaration on addressing health inequalities by presenting a systematic review of evidence on the role of social determinants on prostate cancer in Caribbean men. It aims to determine the distribution, by known social determinants of health, of the frequency and adverse outcomes of prostate cancer among Caribbean populations.

Methods

Observational studies reporting an association between a social determinant and prostate cancer frequency and outcomes were sought in MEDLINE, EMBASE, SciELO, CINAHL, CUMED, LILACS, and IBECS databases. Fourteen social determinants and 7 prostate cancer endpoints were chosen, providing 98 possible relationship groups exploring the role of social determinants on prostate cancer. Observational studies with > 50 participants conducted in Caribbean territories between 2004 and 2016 were eligible. The review was conducted according to STROBE and PRISMA guidelines. Random-effects meta-analyses were performed.

Results

From 843 potentially relevant citations, 13 articles from 9 studies were included. From these included studies, 24 relationships were reported looking at 11 distinct relationship groups, leaving 90 relationship groups (92% of all relationship groups) unexplored. Study heterogeneity and risk of bias restricted results to a narrative synthesis in most instances. Meta-analyses showed more diagnosed prostate cancer among men with less formal education (n = 2 studies, OR 1.60, 95%CI 1.18–2.19) and among men who were married (n = 3 studies, OR 1.54, 95%CI 1.22–1.95).

Conclusions

This review highlights limited evidence for a higher occurrence of diagnosed prostate cancer among Caribbean men with lower levels of education and among men who are married. The role of social determinants on prostate cancer among Caribbean men remains poorly understood. Improvements in study quantity and quality, and reduced variability in outcomes and reporting are needed. This report represents the current evidence, and provides a roadmap to future research priorities for a better understanding of Caribbean prostate cancer inequalities.
Appendix
Available only for authorised users
Literature
1.
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380:2095–128.CrossRefPubMed
2.
3.
Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, et al. Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. PLoS Genet. 2011;7:e1001387.CrossRefPubMedPubMedCentral
4.
5.
6.
7.
8.
Gilligan T. Social disparities and prostate cancer: mapping the gaps in our knowledge. Cancer Causes Control. 2005;16:45–53.CrossRefPubMed
9.
10.
Krieger N, Quesenberry C Jr, Peng T, Horn-Ross P, Stewart S, Brown S, et al. Social class, race/ethnicity, and incidence of breast, cervix, colon, lung, and prostate cancer among Asian, black, Hispanic, and white residents of the San Francisco Bay Area, 1988–92 (United States). Cancer Causes Control. 1999;10:525–37.CrossRefPubMed
11.
12.
Dickey SL, Cormier EM, Whyte J, Graven L, Ralston PA. Demographic, social support, and community differences in predictors of African-American and white men receiving prostate cancer screening in the United States. Public Health Nurs. 2016;33(6):483–92.CrossRefPubMed
13.
Guessous I, Cullati S, Fedewa SA, Burton-Jeangros C, Courvoisier DS, Manor O, et al. Prostate cancer screening in Switzerland: 20-year trends and socioeconomic disparities. Prev Med. 2016;82:83–91.CrossRefPubMed
14.
Nikolaidis C, Tentes I, Lialiaris T, Constantinidis TC, Kortsaris A. Regional disparities in cancer mortality across the rural-urban axis: a case study from North-Eastern Greece. Rural Remote Health. 2015;15:3013.PubMed
15.
16.
Sobers-Grannum N, Murphy MM, Nielsen A, Guell C, Samuels TA, Bishop L, et al. Female gender is a social determinant of diabetes in the Caribbean: a systematic review and meta-analysis. PLoS One. 2015;10(5):e0. 126799CrossRef
17.
O’Neill J, Tabish H, Welch V, Petticrew M, Pottie K, Clarke M, et al. Applying an equity lens to interventions: using PROGRESS ensures consideration of socially stratifying factors to illuminate inequities in health. J Clin Epidemiol. 2014;67:56–64.CrossRefPubMed
18.
19.
20.
21.
22.
23.
24.
25.
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde J. Research electronic data capture (REDCap) - a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42:377–81.CrossRefPubMed
26.
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344–9.CrossRefPubMed
27.
Welch V, Petticrew M, Tugwell P, Moher D, O’Neill J, Waters E, et al. PRISMA-equity 2012 extension: reporting guidelines for systematic reviews with a focus on health equity. PLoS Med. 2012;9:e1001333.CrossRefPubMedPubMedCentral
28.
29.
30.
Fernández L, Galán Y, Jiménez R, Gutiérrez Á, Guerra M, Pereda CM, et al. Estudio de casos y controles sobre factores de riesgo de cáncer de próstata. Rev Cubana Salud Pública. 2005;31:174–81.
31.
Fernández L, Galán Y, Jiménez R, Gutiérrez Á, Guerra M, Pereda C, et al. Sexual behaviour, history of sexually transmitted diseases, and the risk of prostate cancer: a case–control study in Cuba. Int J Epidemiol. 2005;34:193–7.CrossRefPubMed
32.
Jackson M, Tulloch-Reid M, Walker S, McFarlane-Anderson N, Bennett F, Francis D, et al. Dietary patterns as predictors of prostate cancer in Jamaican men. Nutr Cancer. 2013;65:367–74.CrossRefPubMed
33.
Nemesure B, Wu S-Y, Hennis A, Leske MC. Family history of prostate cancer in a black population. J Immigr Minor Health. 2013;15:1107–12.CrossRefPubMed
34.
Soto-Salgado M, Suárez E, Torres-Cintrón M, Pettaway CA, Colón V, Ortiz AP. Prostate cancer incidence and mortality among Puerto Ricans: an updated analysis comparing men in Puerto Rico with US racial/ethnic groups. P R Health Sci J. 2012;31:107–13.PubMed
35.
Jackson MD, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, et al. Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. Cancer Causes Control. 2012;23:23–33.CrossRefPubMed
36.
McDonald AC, Jenkins FJ, Bunker CH, Wilson JW, Patrick AL, Weissfeld JL. A case-cohort study of human herpesvirus 8 seropositivity and incident prostate cancer in Tobago. Infect Agent Cancer. 2011;6:25.CrossRefPubMedPubMedCentral
37.
Multigner L, Ndong JR, Giusti A, Romana M, Delacroix-Maillard H, Cordier S, et al. Chlordecone exposure and risk of prostate cancer. J Clin Oncol. 2010;28:3457–62.CrossRefPubMed
38.
Torres-Cintrón M, Ortiz AP, Ortiz-Ortiz KJ, Figueroa-Vallés NR, Pérez-Irizarry J, Díaz-Medina G, et al. Using a socioeconomic position index to assess disparities in cancer incidence and mortality, Puerto Rico, 1995-2004. Prev Chronic Dis. 2012;9:E15.PubMed
39.
Jackson MD, Tulloch-Reid MK, Lindsay CM, Smith G, Bennett FI, McFarlane-Anderson N, et al. Both serum 25-hydroxyvitamin D and calcium levels may increase the risk of incident prostate cancer in Caribbean men of African ancestry. Cancer Med. 2015;4:925–35.CrossRefPubMedPubMedCentral
40.
Santana RS, Santana ÁLS, García ICC, Cisnero MB. Mortalidad por tumores malignos en Santiago de Cuba durante 2010. Medisan. 2011;15:1510–6.
41.
Smit E, Garcia-Palmieri MR, Figueroa NR, McGee DL, Messina M, Freudenheim JL, et al. Protein and legume intake and prostate cancer mortality in Puerto Rican men. Nutr Cancer. 2007;58:146–52.CrossRefPubMed
42.
Bray F, Piñeros M. Cancer patterns, trends and projections in Latin America and the Caribbean: a global context. Salud Publica Mex. 2016;58:104–17.CrossRefPubMed
43.
44.
Baade PD, Yu XQ, Smith DP, Dunn J, Chambers SK. Geographic disparities in prostate cancer outcomes--review of international patterns. Asian Pac J Cancer Prev. 2015;16:1259–75.CrossRefPubMed
45.
Cheng I, Witte JS, McClure LA, Shema SJ, Cockburn MG, John EM, et al. Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California. Cancer Causes Control. 2009;20:1431–40.CrossRefPubMedPubMedCentral
46.
47.
48.
La Vecchia C, Franceschi S, Talamini R, Negri E, Boyle P, D’Avanzo B. Marital status, indicators of sexual activity and prostatic cancer. J Epidemiol Community Health. 1993;47:450–3.CrossRefPubMedPubMedCentral
49.
Newell GR, Pollack ES, Spitz MR, Sider JG, Fueger JJ. Incidence of prostate cancer and marital status. J Natl Cancer Inst. 1987;79:259–62.PubMed
50.
51.
Dean LT, Subramanian SV, Williams DR, Armstrong K, Charles CZ, Kawachi I. Getting black men to undergo prostate cancer screening the role of social capital. Am J Mens Health. 2014;9:385–96.CrossRefPubMedPubMedCentral
52.
Rosenblatt KA, Wicklund KG, Stanford JL. Sexual factors and the risk of prostate Cancer. Am J Epidemiol. 2001;153:1152–8.CrossRefPubMed
53.
Dennis LK, Dawson DV. Meta-analysis of measures of sexual activity and prostate cancer. Epidemiology. 2002;13:72–9.CrossRefPubMed
54.
Lian W-Q, Luo F, Song X-L, Lu Y-J, Zhao S-C. Gonorrhea and prostate cancer incidence: an updated meta-analysis of 21 epidemiologic studies. Med Sci Monit. 2015;21:1895–903.CrossRefPubMedCentral
55.
Bae J-M. Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis. Epidemiol Health. 2015;17:e2015005.CrossRef
56.
Tyson MD, Andrews PE, Etzioni DA, Ferrigni RG, Humphreys MR, Swanson SK, et al. Marital status and prostate cancer outcomes. Can J Urol. 2013;20:6702–6.PubMed
57.
Evans S, Metcalfe C, Ibrahim F, Persad R, Ben-Shlomo Y. Investigating black-white differences in prostate cancer prognosis: a systematic review and meta-analysis. Int J Cancer. 2008;123:430–5.CrossRefPubMed
58.
Keshava C, McCanlies EC, Weston A. CYP3A4 polymorphisms--potential risk factors for breast and prostate cancer: a HuGE review. Am J Epidemiol. 2004;160:825–41.CrossRefPubMed
59.
Zeigler-Johnson CM, Walker AH, Mancke B, Spangler E, Jalloh M, McBride S, et al. Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4. Hum Hered. 2002;54:13–21.CrossRefPubMed
60.
Hambleton IR, Howitt C, Jeyaseelan S, Murphy MM, Hennis AJ, Wilks R, et al. Trends in longevity in the Americas: disparities in life expectancy in women and men, 1965-2010. PLoS One. 2015;10:e0129778.CrossRefPubMedPubMedCentral
61.
Torres R, Santos E, Orraca L, Elias A, Palacios C. Diet quality, social determinants, and weight status in Puerto Rican children aged 12 years. J Acad Nutr Diet. 2014;114:1230–5.CrossRefPubMedPubMedCentral
62.
63.
64.
Bunker CH, Patrick AL, Konety BR, Dhir R, Brufsky AM, Vivas CA, et al. High prevalence of screening-detected prostate cancer among Afro-Caribbeans: the Tobago Prostate Cancer Survey. Cancer Epidemiol Biomarkers Prev. 2002;11:726–9.PubMed
Metadata
Title
Social determinants of prostate cancer in the Caribbean: a systematic review and meta-analysis
Authors
Catherine R. Brown
Ian Hambleton
Shawn M. Hercules
Nigel Unwin
Madhuvanti M. Murphy
E. Nigel Harris
Rainford Wilks
Marlene MacLeish
Louis Sullivan
Natasha Sobers-Grannum
The U.S. Caribbean Alliance for Health Disparities Research Group (USCAHDR)
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2018
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-018-5696-y

Other articles of this Issue 1/2018

BMC Public Health 1/2018 Go to the issue

Research article

Short-term changes in nightlife attendance and patron intoxication following alcohol restrictions in Queensland, Australia

Research article

Social value of a nutritional counselling and support program for breastfeeding in urban poor settings, Nairobi

Research article

Local professionals’ perceptions of health assets in a low-SES Dutch neighbourhood: a qualitative study

Research article

Choice architecture modifies fruit and vegetable purchasing in a university campus grocery store: time series modelling of a natural experiment

Research article

Arthritis diagnosis and symptoms are positively associated with specific physical job exposures in lower- and middle-income countries: cross-sectional results from the World Health Organization’s Study on global AGEing and adult health (SAGE)

Research article

Running on a high: parkrun and personal well-being