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Published in:

01-06-2014 | Original Article

Smooth Muscle Cell Phenotypic Switching in Stroke

Authors: Marine Poittevin, Pierre Lozeron, Rose Hilal, Bernard I. Levy, Tatiana Merkulova-Rainon, Nathalie Kubis

Published in: Translational Stroke Research | Issue 3/2014

Abstract

Disruption of cerebral blood flow after stroke induces cerebral tissue injury through multiple mechanisms that are not yet fully understood. Smooth muscle cells (SMCs) in blood vessel walls play a key role in cerebral blood flow control. Cerebral ischemia triggers these cells to switch to a phenotype that will be either detrimental or beneficial to brain repair. Moreover, SMC can be primarily affected genetically or by toxic metabolic molecules. After stroke, this pathological phenotype has an impact on the incidence, pattern, severity, and outcome of the cerebral ischemic disease. Although little research has been conducted on the pathological role and molecular mechanisms of SMC in cerebrovascular ischemic diseases, some therapeutic targets have already been identified and could be considered for further pharmacological development. We examine these different aspects in this review.

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Title: Smooth Muscle Cell Phenotypic Switching in Stroke
Authors: Marine Poittevin
Pierre Lozeron
Rose Hilal
Bernard I. Levy
Tatiana Merkulova-Rainon
Nathalie Kubis
Publication date: 01-06-2014
Publisher: Springer US
Published in: Translational Stroke Research / Issue 3/2014
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-013-0306-x

At a glance: The STEP trials

Springer Medicine

Smooth Muscle Cell Phenotypic Switching in Stroke

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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