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BMC Cancer
Published in: BMC Cancer 1/2014

Open Access 01-12-2014 | Research article

Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology

Authors: Emily A Vucic, Kelsie L Thu, Larissa A Pikor, Katey SS Enfield, John Yee, John C English, Calum E MacAulay, Stephen Lam, Igor Jurisica, Wan L Lam

Published in: BMC Cancer | Issue 1/2014

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Abstract

Background

Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on smoking status, suggesting divergent mechanisms underlie tumorigenesis in smokers and non-smokers. MicroRNAs (miRNAs) are integral contributors to tumorigenesis and mediate biological responses to smoking. Based on the hypothesis that smoking-specific miRNA differences in lung adenocarcinomas reflect distinct tumorigenic processes selected by different smoking and non-smoking environments, we investigated the contribution of miRNA disruption to lung tumor biology and patient outcome in the context of smoking status.

Methods

We applied a whole transcriptome sequencing based approach to interrogate miRNA levels in 94 patient-matched lung adenocarcinoma and non-malignant lung parenchymal tissue pairs from current, former and never smokers.

Results

We discovered novel and distinct smoking status-specific patterns of miRNA and miRNA-mediated gene networks, and identified miRNAs that were prognostically significant in a smoking dependent manner.

Conclusions

We conclude that miRNAs disrupted in a smoking status-dependent manner affect distinct cellular pathways and differentially influence lung cancer patient prognosis in current, former and never smokers. Our findings may represent promising biologically relevant markers for lung cancer prognosis or therapeutic intervention.
Appendix
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Metadata
Title
Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology
Authors
Emily A Vucic
Kelsie L Thu
Larissa A Pikor
Katey SS Enfield
John Yee
John C English
Calum E MacAulay
Stephen Lam
Igor Jurisica
Wan L Lam
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-14-778

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