Top

Published in:

01-01-2016 | Clinical Quiz

“Smoking” guns: Answers

Authors: Tammi Cooks, T. Keefe Davis, June Hu, Rachel Metheny, Michael Schwartz, Roy Gerona

Published in: Pediatric Nephrology | Issue 1/2016

Excerpt

Toxicology studies identified AB-FUBINACA, a fifth generation synthetic cannabinoid (SC), in the urine (450 ng/mL) and serum (52 ng/mL). Acute kidney injury (AKI) secondary to SCs was brought to international attention in a report from the U.S. Centers for Disease Control and Prevention in February 2013 [1] which detailed 16 cases of AKI after SC use in six states. A case series of four patients from Alabama, all from the same county, also implicated SCs as a cause of AKI [2]. An additional case has since been reported [3]. This is the first report of a fifth generation SC associated with AKI. …

U.S. Centers for Disease Control and Prevention (CDC) (2013) Acute kidney injury associated with synthetic cannabinoid use—multiple states, 2012. MMWR Morb Mortal Wkly Rep 62:93–98

Bhanushali GK, Jain G, Fatima H, Leisch LJ, Thornley-Brown D (2013) AKI associated with synthetic cannabinoids: a case series. Clin J Am Soc Nephrol 8:523–526PubMedCentralCrossRefPubMed

Kazory A, Aiyer R (2013) Synthetic marijuana and acute kidney injury: an unforeseen association. Clin Kidney J 6:330–333PubMedCentralCrossRefPubMed

Hohmann N, Mikus G, Czock D (2014) Effects and risks associated with novel psychoactive substances: mislabeling and sale as bath salts, spice, and research chemicals. Dtsch Arztebl Int 111:139–147PubMedCentralPubMed

Office of Diversion Control, Drug Enforcement Administration, U.S. Department of Justice (2012) Available at: http://www.deadiversion.usdoj.gov/fed_regs/rules/2012/fr0301_3.htm. Accessed 8 Sept 2014

Office of Diversion Control, Drug Enforcement Administration, U.S. Department of Justice (2013) Available at: http://www.deadiversion.usdoj.gov/fed_regs/rules/2013/fr0516.htm. Accessed 8 Sept 2014

Office of Diversion Control, Drug Enforcement Administration, U.S. Department of Justice (2014) Available at: http://www.deadiversion.usdoj.gov/fed_regs/rules/2014/fr0210.htm. Accessed 8 Sept 2014

Johnston D, O’Malley PM, Miech RA, Bachman JG, Schulenberg JE; The University of Michigan Institute for Social Research (2013) Monitoring the future. National results on drug use. 2013 overview. Key findings on adolescent drug use. Available at: http://www.monitoringthefuture.org/pubs/monographs/mtf-overview2013.pdf. Accessed 8 Sept 2014

Wiebelhaus JM, Poklis JL, Poklis A, Vann RE, Lichtman AH, Wise LE (2012) Inhalation exposure to smoke from synthetic "marijuana" produces potent cannabimimetic effects in mice. Drug Alcohol Depend 126:316–323PubMedCentralCrossRefPubMed

10.

Thornton SL, Wood C, Friesen MW, Gerona RR (2013) Synthetic cannabinoid use associated with acute kidney injury. Clin Toxicol 51:189–190CrossRef

11.

Durand D, Delgado LL, de la Parra-Pellot DM, Nichols-Vinueza D (2013) Psychosis and severe rhabdomyolysis associated with synthetic cannabinoid use. Clin Schizophr Relat Psychoses 21:1–13

12.

Kunz SN, Grove N, Fischer F (2012) Acute pathophysiological influences of conducted electrical weapons in humans: A review of current literature. Forensic Sci Int 221:1–4CrossRefPubMed

13.

Kroll MW (2009) Physiology and pathology of TASER electronic control devices. J Forensic Leg Med16:173–177CrossRefPubMed

14.

Ordog GJ, Wasserberger J, Schlater T, Balasubramanium S (1987) Electronic gun (TASER) injuries. Ann Emerg Med 16:73–78CrossRefPubMed

15.

Pasquier M, Carron PN, Vallotton L, Yersin B (2011) Electronic control device exposure: a review of morbidity and mortality. Ann Emerg Med 58:178–188CrossRefPubMed

16.

Gross ER, Porterieko J, Joseph D (2013) Rhabdomyolysis and oliguric renal failure after use of TASER(R): is it really safe? Am Surg 79:E337–E339PubMed

17.

Sanford JM, Jacobs GJ, Roe EJ, Terndrup TE (2011) Two patients subdued with a TASER(R) device: cases and review of complications. J Emerg Med 40:28–32CrossRefPubMed

18.

Ho JD, Dawes DM (2011) TASER device-induced rhabdomyolysis is unlikely. J Emerg Med 40:68–69, author reply 69CrossRefPubMed

19.

Dawes DM, Ho JD, Sweeney JD, Lundin EJ, Kunz SN, Miner JR (2011) The effect of an electronic control device on muscle injury as determined by creatine kinase enzyme. Forensic Sci Med Pathol 7:3–8CrossRefPubMed

20.

Dawes DM, Ho JD, Reardon RF, Sweeney JD, Miner JR (2010) The physiologic effects of multiple simultaneous electronic control device discharges. West J Emerg Med 11:49–56PubMedCentralPubMed

21.

Dawes DM, Ho JD, Reardon RF, Strote SR, Nelson RS, Lundin EJ, Orozco BS, Kunz SN, Miner JR (2011) The respiratory, metabolic, and neuroendocrine effects of a new generation electronic control device. Forensic Sci Int 207:55–60CrossRefPubMed

22.

Ho JD, Miner JR, Lakireddy DR, Bultman LL, Heegaard WG (2006) Cardiovascular and physiologic effects of conducted electrical weapon discharge in resting adults. Acad Emerg Med 13:589–595CrossRefPubMed

23.

Dawes DM, Ho JD, Reardon RF, Miner JR (2010) The cardiovascular, respiratory, and metabolic effects of a long duration electronic control device exposure in human volunteers. Forensic Sci Med Pathol 6:268–274CrossRefPubMed

24.

Ho JD, Dawes DM, Nelson RS, Lundin EJ, Ryan FJ, Overton KG, Zeiders AJ, Miner JR (2010) Acidosis and catecholamine evaluation following simulated law enforcement "use of force" encounters. Acad Emerg Med 17:e60–e68CrossRefPubMed

25.

Bozeman WP, Hauda WE 2nd, Heck JJ, Graham DD Jr, Martin BP, Winslow JE (2009) Safety and injury profile of conducted electrical weapons used by law enforcement officers against criminal suspects. Ann Emerg Med 53:480–489CrossRefPubMed

26.

American Association of Poison Control Centers. Available at: http://www.aapcc.org/alerts/synthetic-marijuana/htm Accessed 8 Sept 2014

Title: “Smoking” guns: Answers
Authors: Tammi Cooks
T. Keefe Davis
June Hu
Rachel Metheny
Michael Schwartz
Roy Gerona
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 1/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2983-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

“Smoking” guns: Answers

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 1/2016

Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort

Erratum to: Risk factors for relapse and long-term outcome in steroid-dependent nephrotic syndrome treated with rituximab

Peritoneal–pericardial communication in an adolescent on peritoneal dialysis

“Smoking” guns: Questions

Role of new biomarkers for predicting renal scarring in vesicoureteral reflux: NGAL, KIM-1, and L-FABP

Insignificant impact of VUR on the progression of CKD in children with CAKUT