Skip to main content
Top
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery 3/2018

01-09-2018 | Clinical Report

Small Cell Neuroendocrine Carcinoma: A Rare Nasopharyngeal Malignancy with Aggressive Clinical Course

Authors: Nishu Bhardwaj, Aanchal Kakkar, David Victor Kumar Irugu

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery | Issue 3/2018

Login to get access

Abstract

Primary small cell neuroendocrine carcinoma is uncommon in head and neck region, with occasional cases in nasopharynx. Distinction from other round cell tumors is imperative to ensure optimal patient management. We present a case of a 30-year-old woman who presented with a rapidly growing nasopharyngeal mass.
Literature
1.
go back to reference Lin IH, Hwang CF, Huang HY (2007) Small cell carcinoma of the nasopharynx. Acta Otolaryngol 127:206–208CrossRefPubMed Lin IH, Hwang CF, Huang HY (2007) Small cell carcinoma of the nasopharynx. Acta Otolaryngol 127:206–208CrossRefPubMed
2.
go back to reference Shunyu N, Lynrah Z, Goyal A, Raphal V (2012) Small-cell neuroendocrine carcinoma of nasopharynx. Clin Rhinol Int J 5:130–131CrossRef Shunyu N, Lynrah Z, Goyal A, Raphal V (2012) Small-cell neuroendocrine carcinoma of nasopharynx. Clin Rhinol Int J 5:130–131CrossRef
3.
go back to reference Bellahammou K, Lakhdissi A, Akkar O, Kouhen F, Rais F, Dahraoui S, M’rabti H, Errihani H (2017) Small-cell neuroendocrine carcinoma of nasopharynx: a case report. IJSM 3:132–135 Bellahammou K, Lakhdissi A, Akkar O, Kouhen F, Rais F, Dahraoui S, M’rabti H, Errihani H (2017) Small-cell neuroendocrine carcinoma of nasopharynx: a case report. IJSM 3:132–135
4.
go back to reference Aguiar A, Jacome M, Azevedo I, Monteiro E, Castro V (2015) Small-Cell neuroendocrine carcinoma originating from the nasopharynx: report of a rare case. Rep Radiother Oncol 2:E3814 Aguiar A, Jacome M, Azevedo I, Monteiro E, Castro V (2015) Small-Cell neuroendocrine carcinoma originating from the nasopharynx: report of a rare case. Rep Radiother Oncol 2:E3814
5.
go back to reference Perez-Ordonez B, Bishop JA, Gnepp DR, Hunt JL, Thompson LDR (2017) Neuroendocrine tumours. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (eds) WHO classification of head and neck tumours. IARC, Lyon, pp 95–98 Perez-Ordonez B, Bishop JA, Gnepp DR, Hunt JL, Thompson LDR (2017) Neuroendocrine tumours. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (eds) WHO classification of head and neck tumours. IARC, Lyon, pp 95–98
6.
go back to reference Mills SE (2002) Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol 15:264–278CrossRefPubMed Mills SE (2002) Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol 15:264–278CrossRefPubMed
7.
go back to reference Deviprasad S, Rajeshwari A, Tahir M, Adarsha T, Gangadhara S (2008) Small cell neuroendocrine carcinoma originating from the lateral nasopharyngeal wall. Ear Nose Throat J 87:E1–E3PubMed Deviprasad S, Rajeshwari A, Tahir M, Adarsha T, Gangadhara S (2008) Small cell neuroendocrine carcinoma originating from the lateral nasopharyngeal wall. Ear Nose Throat J 87:E1–E3PubMed
8.
go back to reference Wenig BL, Gnepp DR (1989) The spectrum of neuroendocrine carcinomas of the larynx. Semin Diagn Pathol 6:329–350PubMed Wenig BL, Gnepp DR (1989) The spectrum of neuroendocrine carcinomas of the larynx. Semin Diagn Pathol 6:329–350PubMed
9.
go back to reference Subha S (2011) Neuroendocrine carcinoma of the nasopharynx: a case report. Med Health Sci 9:101–103CrossRef Subha S (2011) Neuroendocrine carcinoma of the nasopharynx: a case report. Med Health Sci 9:101–103CrossRef
10.
go back to reference Mineta H, Miura K, Takebayashi S (2001) Immunohistochemical analysis of small cell carcinoma of the head and neck: a report of 4 patients and a review of sixteen patients in the literature with ectopic hormone production. Ann Otol Rhinol Laryngol 110:76–82CrossRefPubMed Mineta H, Miura K, Takebayashi S (2001) Immunohistochemical analysis of small cell carcinoma of the head and neck: a report of 4 patients and a review of sixteen patients in the literature with ectopic hormone production. Ann Otol Rhinol Laryngol 110:76–82CrossRefPubMed
11.
go back to reference Nandi M, Arun I, Bhattacharya A, Sen S, Ray S, Mallick I (2014) Reporting of a primary sinonasal neuroendocrine small cell carcinoma in the paediatric age group. Head Neck Oncol 6:5 Nandi M, Arun I, Bhattacharya A, Sen S, Ray S, Mallick I (2014) Reporting of a primary sinonasal neuroendocrine small cell carcinoma in the paediatric age group. Head Neck Oncol 6:5
12.
go back to reference Chen C, Hsu M (2000) Second primary epithelial malignancy of nasopharynx and nasal cavity after successful curative radiation therapy of nasopharyngeal carcinoma. Hum Pathol 31:227–232CrossRefPubMed Chen C, Hsu M (2000) Second primary epithelial malignancy of nasopharynx and nasal cavity after successful curative radiation therapy of nasopharyngeal carcinoma. Hum Pathol 31:227–232CrossRefPubMed
13.
go back to reference Sturgis C, Burkey B, Momin S, Hoschar A (2015) High grade (large cell) neuroendocrine carcinoma of the nasopharynx: novel case report with touch preparation cytology and positive EBV encoded early RNA. Case Rep Pathol 2015. https://doi.org/10.1155/2015/231070 Sturgis C, Burkey B, Momin S, Hoschar A (2015) High grade (large cell) neuroendocrine carcinoma of the nasopharynx: novel case report with touch preparation cytology and positive EBV encoded early RNA. Case Rep Pathol 2015. https://​doi.​org/​10.​1155/​2015/​231070
14.
go back to reference Serrano MF, El-Mofty SK, Gnepp DR (2008) Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol 39:591–598CrossRefPubMed Serrano MF, El-Mofty SK, Gnepp DR (2008) Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol 39:591–598CrossRefPubMed
15.
go back to reference Chapman-Fredricks J, Jorda M, Gomez Fernandez C (2009) A limited Immunohistochemical panel helps differentiate small cell epithelial malignancies of the sinonasal cavity and nasopharynx. Appl Immunohistochem Mol Morphol 17:207–210CrossRefPubMed Chapman-Fredricks J, Jorda M, Gomez Fernandez C (2009) A limited Immunohistochemical panel helps differentiate small cell epithelial malignancies of the sinonasal cavity and nasopharynx. Appl Immunohistochem Mol Morphol 17:207–210CrossRefPubMed
16.
go back to reference Lee LY, Chang KP, Hsu CL, Chen TC, Kuo TT (2011) Small-cell neuroendocrine carcinoma of the nasopharynx: report of a rare case lacking association with Epstein–Barr virus. Int J Surg Pathol 19:199–202CrossRefPubMed Lee LY, Chang KP, Hsu CL, Chen TC, Kuo TT (2011) Small-cell neuroendocrine carcinoma of the nasopharynx: report of a rare case lacking association with Epstein–Barr virus. Int J Surg Pathol 19:199–202CrossRefPubMed
18.
go back to reference Takahashi S, Miyashita T, Hoshikawa H, Haba R, Togami T, Shibata T (2015) Accelerated hyperfractionated radiotherapy for small cell carcinoma of the nasopharynx. Head Neck 37:E63–E65CrossRefPubMed Takahashi S, Miyashita T, Hoshikawa H, Haba R, Togami T, Shibata T (2015) Accelerated hyperfractionated radiotherapy for small cell carcinoma of the nasopharynx. Head Neck 37:E63–E65CrossRefPubMed
19.
go back to reference Galera-Ruiz H, Villar-Rodriguez JL, Sanchez-Calzado JA (2001) Sinonasal neuroendocrine carcinoma presenting as a nasopharyngeal mass. Otolaryngol Head Neck Surg 124:475–476CrossRefPubMed Galera-Ruiz H, Villar-Rodriguez JL, Sanchez-Calzado JA (2001) Sinonasal neuroendocrine carcinoma presenting as a nasopharyngeal mass. Otolaryngol Head Neck Surg 124:475–476CrossRefPubMed
20.
go back to reference Galanis E, Frytak S, Lloyd RV (1997) Extrapulmonary small cell carcinoma. Cancer 79(1729–3):6 Galanis E, Frytak S, Lloyd RV (1997) Extrapulmonary small cell carcinoma. Cancer 79(1729–3):6
21.
go back to reference Pointer KB, Ko HC, Brower JV, Witek ME, Kimple RJ, Lloyd RV, Harari PM, Baschnagel AM (2017) Small cell carcinoma of the head and neck: an analysis of the National Cancer Database. Oral Oncol 69:92–98CrossRefPubMedPubMedCentral Pointer KB, Ko HC, Brower JV, Witek ME, Kimple RJ, Lloyd RV, Harari PM, Baschnagel AM (2017) Small cell carcinoma of the head and neck: an analysis of the National Cancer Database. Oral Oncol 69:92–98CrossRefPubMedPubMedCentral
22.
go back to reference Mohebbi A, Daneshi A, Emami AR (2008) Nasopharyngeal neuroendocrine carcinoma: A case report. Ear Nose Throat J 87:E4 Mohebbi A, Daneshi A, Emami AR (2008) Nasopharyngeal neuroendocrine carcinoma: A case report. Ear Nose Throat J 87:E4
23.
go back to reference Hatoum GF, Patton B, Takita C (2009) Small cell carcinoma of the head and neck: the university of Miami experience. Int J Radiat Oncol Biol Phys 74:477–481CrossRefPubMed Hatoum GF, Patton B, Takita C (2009) Small cell carcinoma of the head and neck: the university of Miami experience. Int J Radiat Oncol Biol Phys 74:477–481CrossRefPubMed
24.
go back to reference Azevedo D, Rios E, Vendeira L, Sarmento C (2017) Small cell neuroendocrine carcinoma of the nasopharynx: a rare case report. Autopsy Case Rep 7:31–35CrossRef Azevedo D, Rios E, Vendeira L, Sarmento C (2017) Small cell neuroendocrine carcinoma of the nasopharynx: a rare case report. Autopsy Case Rep 7:31–35CrossRef
Metadata
Title
Small Cell Neuroendocrine Carcinoma: A Rare Nasopharyngeal Malignancy with Aggressive Clinical Course
Authors
Nishu Bhardwaj
Aanchal Kakkar
David Victor Kumar Irugu
Publication date
01-09-2018
Publisher
Springer India
Published in
Indian Journal of Otolaryngology and Head & Neck Surgery / Issue 3/2018
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-018-1344-1

Other articles of this Issue 3/2018

Indian Journal of Otolaryngology and Head & Neck Surgery 3/2018 Go to the issue