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Open Access 01-12-2006 | Review

Smad signalling in the ovary

Authors: Noora Kaivo-oja, Luke A Jeffery, Olli Ritvos, David G Mottershead

Published in: Reproductive Biology and Endocrinology | Issue 1/2006

Abstract

It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) superfamily. In the ovary, several TGF-beta superfamily members are expressed by the oocyte, granulosa and thecal cells at different stages of folliculogenesis, and they signal mainly through two different Smad pathways in an autocrine/paracrine manner. Defects in the upstream signalling cascade molecules, the ligands and receptors, are known to have adverse effects on ovarian organogenesis and folliculogenesis, but the role of the individual Smad proteins in the proper function of the ovary is just beginning to be understood for example through the use of Smad knockout models. Although most of the different Smad knockouts are embryonic lethal, it is known, however, that in Smad1 and Smad5 knockout mice primordial germ cell development is impaired and that Smad3 deficient mice harbouring a deletion in exon 8 exhibit impaired folliculogenesis and reduced fertility. In this minireview we discuss the role of Smad structure and function in the ovarian context.

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Title: Smad signalling in the ovary
Authors: Noora Kaivo-oja
Luke A Jeffery
Olli Ritvos
David G Mottershead
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2006
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/1477-7827-4-21

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Smad signalling in the ovary

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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