A 48-year-old woman with depression was intubated on admission to the intensive care unit for deep coma of unknown origin. Post-intubation chest X-ray showed the intragastric presence of a radio-opaque pharmacobezoar with 22 tablets (Fig. 1). Toxicology screening results and information from the family confirmed a witnessed intake of a slow-release preparation of clomipramine (Anafranil-Retard 75 mg, depot tablets) 12 h before admission.