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Sleep and Breathing

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08-07-2023 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Apnea-hypopnea index and the polysomnographic risk factors for predicting 5- to 8-year mortality in patients with OSA

Authors: Yelda Varol, Zeynep Zeren Uçar, Burcu Oktay Arslan, Işıl Karasu

Published in: Sleep and Breathing | Issue 1/2024

Abstract

Background

The purpose of this study was to investigate the long-term mortality rates of patients with obstructive sleep apnea (OSA) who received an overnight polysomnogram (PSG) for obtaining the diagnosis and to determine the relationship between PSG parameters and overall mortality.

Methods

Between 2007 and 2013, patients who had overnight PSG and were diagnosed with OSA were included in the study. Factors which are thought to influence mortality were assessed for 5-year and overall survival using the log rank test and Kaplan-Meier survival curves. Using multivariable Cox regression analysis, a model was constructed for factors influencing 5-year and overall survival.

Results

A total of 762 patients with a mean age of 52.7 (±10.8) and a dominance of men (74.7%) were studied. Gender, OSA severity subgroups, and apnea hypopnea index (AHI) were not statistically significantly associated with either 5-year or overall mortality (p<0.05 for both). Age, having a cardiovascular comorbidity, proportion of rapid eye movement (%REM), and total sleep time with an oxyhemoglobin saturation of less than 90% (T90) all showed a significant correlation with overall all-cause mortality in the model. For 5-year mortality and overall mortality, the hazard ration (HR) for T90 was 3.6 (95% CI (1.6–8.0) p=0.001) and 3 (95% CI (1.6–5.7) p=0.001), respectively.

Conclusion

The study findings suggest that not AHI but PSG parameters of hypoxia, mainly T90, having cardiovascular comorbidity, and %REM sleep were significant risk factors for all-cause mortality in patients with OSA. The association of OSA, hypoxia, and mortality is an area that deserves further study.

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Title: Apnea-hypopnea index and the polysomnographic risk factors for predicting 5- to 8-year mortality in patients with OSA
Authors: Yelda Varol
Zeynep Zeren Uçar
Burcu Oktay Arslan
Işıl Karasu
Publication date: 08-07-2023
Publisher: Springer International Publishing
Keywords: Sleep Apnea
Polysomnography
Published in: Sleep and Breathing / Issue 1/2024
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-023-02868-3

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Abstract

Background

Methods

Results

Conclusion

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