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Published in: Current Neurology and Neuroscience Reports 8/2018

01-08-2018 | Sleep (M Thorpy and M Billiard, Section Editors)

Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia

Authors: Antonio Culebras, Sanam Anwar

Published in: Current Neurology and Neuroscience Reports | Issue 8/2018

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Abstract

Purpose of Review

In this article, we review the cerebrovascular complications of sleep apnea (SA). SA is the major sleep disorder associated with stroke and vascular dementia.

Recent Findings

Sleep apnea syndrome of moderate to severe intensity affects 17% of 50–70-year-old men and 9% of 50–70-year-old women, making SA a notorious and prevalent disorder. SA increases the risk of hypertension, stroke, myocardial infarction, and atrial fibrillation (AF) and is closely linked to vascular dementia. In addition, SA may worsen the neurologic outcome in acute stroke patients and interferes with rehabilitation after stroke.

Summary

Proper management of SA may decrease the clinical impact of stroke risk factors, improve neurologic outcome after stroke, and lessen the progression of subcortical ischemic vascular disease. In this article, we will cover the most salient pathologies that associate SA and cerebrovascular pathology.
Literature
1.
go back to reference Culebras A editor. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013. Culebras A editor. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013.
2.
go back to reference Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–14.CrossRefPubMedPubMedCentral Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–14.CrossRefPubMedPubMedCentral
5.
go back to reference Gastaut H, Tassinari CA, Duron B. Polygraphic study of diurnal and nocturnal (hypnic and respiratory) episodal manifestations of Pickwick syndrome. Rev Neurol (Paris). 1965;112:568–79. Gastaut H, Tassinari CA, Duron B. Polygraphic study of diurnal and nocturnal (hypnic and respiratory) episodal manifestations of Pickwick syndrome. Rev Neurol (Paris). 1965;112:568–79.
6.
go back to reference Dickens C. The posthumous papers of the Pickwick Club. 1867. Dickens C. The posthumous papers of the Pickwick Club. 1867.
8.
go back to reference •• American Academy of Sleep Medicine. International Classification of Sleep Disorders, 3rd ed. Darien, ILL; American Academy of Sleep Medicine. 2014. Codifies all sleep disorders . •• American Academy of Sleep Medicine. International Classification of Sleep Disorders, 3rd ed. Darien, ILL; American Academy of Sleep Medicine. 2014. Codifies all sleep disorders .
9.
go back to reference American Academy of Sleep Medicine - Hidden Health Crisis report, 2016. Prevalence, Diagnosis and treatment of sleep apnea in the United States. American Academy of Sleep Medicine - Hidden Health Crisis report, 2016. Prevalence, Diagnosis and treatment of sleep apnea in the United States.
10.
go back to reference Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.CrossRefPubMed Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.CrossRefPubMed
11.
go back to reference Gami AS, Hodge DO, Herges RM, Olson EJ, Nykodym J, Kara T, et al. Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. J Am Coll Cardiol. 2007;49(5):565–71. Gami AS, Hodge DO, Herges RM, Olson EJ, Nykodym J, Kara T, et al. Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. J Am Coll Cardiol. 2007;49(5):565–71.
12.
go back to reference Román GC. In: Culebras A, editor. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013. Román GC. In: Culebras A, editor. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013.
13.
go back to reference Siccoli MM, Valko PO, Hermann DM, Bassetti CL. Central periodic breathing during sleep in 74 patients with acute ischemic stroke—neurogenic and cardiogenic factors. J Neurol. 2008;255(11):1687–92.CrossRefPubMed Siccoli MM, Valko PO, Hermann DM, Bassetti CL. Central periodic breathing during sleep in 74 patients with acute ischemic stroke—neurogenic and cardiogenic factors. J Neurol. 2008;255(11):1687–92.CrossRefPubMed
14.
go back to reference Robbins J, Redline S, Ervin A, Walsleben JA, Ding J, Nieto FJ. Associations of sleep-disordered breathing and cerebral changes on MRI. J Clin Sleep Med. 2005;1:159–65.PubMed Robbins J, Redline S, Ervin A, Walsleben JA, Ding J, Nieto FJ. Associations of sleep-disordered breathing and cerebral changes on MRI. J Clin Sleep Med. 2005;1:159–65.PubMed
15.
go back to reference Muñoz R, Durán-Cantolla J, Martínez-Vila E, et al. Central sleep apnea is associated with increased risk of ischemic stroke in the elderly. Acta Neurol Scand. 2012;126(3):183–8.CrossRefPubMed Muñoz R, Durán-Cantolla J, Martínez-Vila E, et al. Central sleep apnea is associated with increased risk of ischemic stroke in the elderly. Acta Neurol Scand. 2012;126(3):183–8.CrossRefPubMed
18.
go back to reference Martínez-García MA, Capote F, Campos-Rodríguez F, Lloberes P, Díaz de Atauri MJ, Somoza M, et al. Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial. JAMA. 2013;310(22):2407–15. Martínez-García MA, Capote F, Campos-Rodríguez F, Lloberes P, Díaz de Atauri MJ, Somoza M, et al. Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial. JAMA. 2013;310(22):2407–15.
20.
go back to reference Berger S, Lavie L. Sleep apnea, oxidative stress, proinflammatory vascular risk factors and endothelial disease. In: Culebras A, editor. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013, p. 11. Berger S, Lavie L. Sleep apnea, oxidative stress, proinflammatory vascular risk factors and endothelial disease. In: Culebras A, editor. Sleep, stroke and cardiovascular disease. Cambridge University Press, 2013, p. 11.
22.
go back to reference Capone C, Faraco G, Coleman C, Young CN, Pickel VM, Anrather J, et al. Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension. 2012;60(1):106–13. Capone C, Faraco G, Coleman C, Young CN, Pickel VM, Anrather J, et al. Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension. 2012;60(1):106–13.
23.
go back to reference Narkiewicz K, Montano N, Cogliati C, van de Borne PJH, Dyken ME, Somers VK. Altered cardiovascular variability in obstructive sleep apnea. Circulation. 1998;98(11):1071–7.CrossRefPubMed Narkiewicz K, Montano N, Cogliati C, van de Borne PJH, Dyken ME, Somers VK. Altered cardiovascular variability in obstructive sleep apnea. Circulation. 1998;98(11):1071–7.CrossRefPubMed
24.
go back to reference Nagata K, Osada N, Shimazaki M, et al. Diurnal blood pressure variation in patients with sleep apnea syndrome. Hypertens Res. 2008;31(2):185–91.CrossRefPubMed Nagata K, Osada N, Shimazaki M, et al. Diurnal blood pressure variation in patients with sleep apnea syndrome. Hypertens Res. 2008;31(2):185–91.CrossRefPubMed
25.
go back to reference Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–84.CrossRefPubMed Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–84.CrossRefPubMed
26.
go back to reference Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283(14):1829–36. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000;283(14):1829–36.
27.
go back to reference Hla KM, Young T, Finn L, Peppard PE, Szklo-Coxe M, Stubbs M. Longitudinal association of sleep-disordered breathing and nondipping of nocturnal blood pressure in the Wisconsin Sleep Cohort Study. Sleep. 2008;31(6):795–800.CrossRefPubMedPubMedCentral Hla KM, Young T, Finn L, Peppard PE, Szklo-Coxe M, Stubbs M. Longitudinal association of sleep-disordered breathing and nondipping of nocturnal blood pressure in the Wisconsin Sleep Cohort Study. Sleep. 2008;31(6):795–800.CrossRefPubMedPubMedCentral
28.
go back to reference Logan AG, Perlikowski SM, Mente A, Tisler A, Tkacova R, Niroumand M, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001;19(12):2271–7. Logan AG, Perlikowski SM, Mente A, Tisler A, Tkacova R, Niroumand M, et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001;19(12):2271–7.
29.
go back to reference Walia HK, Li H, Rueschman M, Bhatt DL, Patel SR, Quan SF, et al. Association of severe obstructive sleep apnea and elevated blood pressure despite antihypertensive medication use. J Clin Sleep Med. 2014;10(8):835–43. Walia HK, Li H, Rueschman M, Bhatt DL, Patel SR, Quan SF, et al. Association of severe obstructive sleep apnea and elevated blood pressure despite antihypertensive medication use. J Clin Sleep Med. 2014;10(8):835–43.
30.
go back to reference Guilleminault C, Connolly SJ, Winkle RA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol. 1983;52(5):490–4.CrossRefPubMed Guilleminault C, Connolly SJ, Winkle RA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol. 1983;52(5):490–4.CrossRefPubMed
31.
go back to reference • Culebras A. Double jeopardy: sleep apnea, atrial fibrillation, and stroke. Sleep Med. 2017;30:255–6. The editorial summarizes the state-of-the-art in the association between sleep apnea, atrial fibrillation, and stroke CrossRefPubMed • Culebras A. Double jeopardy: sleep apnea, atrial fibrillation, and stroke. Sleep Med. 2017;30:255–6. The editorial summarizes the state-of-the-art in the association between sleep apnea, atrial fibrillation, and stroke CrossRefPubMed
32.
go back to reference Sauer WH, McKernan ML, Lin D, Gerstenfeld EP, Callans DJ, Marchlinski FE. Clinical predictors and outcomes associated with acute return of pulmonary vein conduction during pulmonary vein isolation for treatment of atrial fibrillation. Heart Rhythm. 2006;3(9):1024–8.CrossRefPubMed Sauer WH, McKernan ML, Lin D, Gerstenfeld EP, Callans DJ, Marchlinski FE. Clinical predictors and outcomes associated with acute return of pulmonary vein conduction during pulmonary vein isolation for treatment of atrial fibrillation. Heart Rhythm. 2006;3(9):1024–8.CrossRefPubMed
33.
go back to reference • Poli M, Philip P, Taillard J, Debruxelles S, Renou P, Orgogozo JM, et al. Atrial fibrillation is a major cause of stroke in apneic patients: a prospective study. Sleep Med. 2017;30:251–4. A most recent prospective study confirming the association between sleep apnea and atrial fibrillation • Poli M, Philip P, Taillard J, Debruxelles S, Renou P, Orgogozo JM, et al. Atrial fibrillation is a major cause of stroke in apneic patients: a prospective study. Sleep Med. 2017;30:251–4. A most recent prospective study confirming the association between sleep apnea and atrial fibrillation
34.
go back to reference Kanagala R, Murali NS, Friedman PA, Ammash NM, Gersh BJ, Ballman KV, et al. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation. 2003;107(20):2589–94. Kanagala R, Murali NS, Friedman PA, Ammash NM, Gersh BJ, Ballman KV, et al. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation. 2003;107(20):2589–94.
35.
go back to reference Patel D, Mohanty P, Di Biase L, et al. Safety and efficacy of pulmonary vein antral isolation in patients with obstructive sleep apnea: the impact of continuous positive airway pressure. Circ Arrhythm Electrophysiol. 2010;3(5):445–51.CrossRefPubMed Patel D, Mohanty P, Di Biase L, et al. Safety and efficacy of pulmonary vein antral isolation in patients with obstructive sleep apnea: the impact of continuous positive airway pressure. Circ Arrhythm Electrophysiol. 2010;3(5):445–51.CrossRefPubMed
36.
go back to reference Holmqvist F, Simon D, Steinberg BA, Hong SJ, Kowey PR, Reiffel JA, et al. Catheter ablation of atrial fibrillation in U.S. community practice—results from outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). J Am Heart Assoc. 2015;4(5):e001901. Holmqvist F, Simon D, Steinberg BA, Hong SJ, Kowey PR, Reiffel JA, et al. Catheter ablation of atrial fibrillation in U.S. community practice—results from outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). J Am Heart Assoc. 2015;4(5):e001901.
37.
go back to reference Fox H, Bitter T, Horstkotte D, Oldenburg O. Cardioversion of atrial fibrillation or atrial flutter into sinus rhythm reduces nocturnal central respiratory events and unmasks obstructive sleep apnoea. Clin Res Cardiol. 2016;105(5):451–9.CrossRefPubMed Fox H, Bitter T, Horstkotte D, Oldenburg O. Cardioversion of atrial fibrillation or atrial flutter into sinus rhythm reduces nocturnal central respiratory events and unmasks obstructive sleep apnoea. Clin Res Cardiol. 2016;105(5):451–9.CrossRefPubMed
38.
go back to reference Naruse Y, Tada H, Satoh M, et al. Radiofrequency catheter ablation of persistent atrial fibrillation decreases a sleep-disordered breathing parameter during a short follow-up period. Circ J. 2012;76(9):2096–103.CrossRefPubMed Naruse Y, Tada H, Satoh M, et al. Radiofrequency catheter ablation of persistent atrial fibrillation decreases a sleep-disordered breathing parameter during a short follow-up period. Circ J. 2012;76(9):2096–103.CrossRefPubMed
40.
go back to reference Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005;172(11):1447–51.CrossRefPubMedPubMedCentral Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005;172(11):1447–51.CrossRefPubMedPubMedCentral
41.
go back to reference Muñoz R, Durán-Cantolla J, Martínez-Vila E, et al. Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke. 2006;37(9):2317–21.CrossRefPubMed Muñoz R, Durán-Cantolla J, Martínez-Vila E, et al. Severe sleep apnea and risk of ischemic stroke in the elderly. Stroke. 2006;37(9):2317–21.CrossRefPubMed
42.
go back to reference Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O’ Connor GT, Resnick HE, et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010;182(2):269–77. Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O’ Connor GT, Resnick HE, et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010;182(2):269–77.
43.
go back to reference Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008;31(8):1071–8. Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008;31(8):1071–8.
44.
go back to reference Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata DM, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(12):3754–832. Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata DM, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(12):3754–832.
45.
go back to reference Lynch JJ, Schuchard GH, Gross CM, Wann LS. Prevalence of right-to-left atrial shunting in a healthy population: detection by Valsalva maneuver contrast echocardiography. Am J Cardiol. 1984;53:1478–806.CrossRefPubMed Lynch JJ, Schuchard GH, Gross CM, Wann LS. Prevalence of right-to-left atrial shunting in a healthy population: detection by Valsalva maneuver contrast echocardiography. Am J Cardiol. 1984;53:1478–806.CrossRefPubMed
46.
go back to reference Beelke M, Angeli S, Del Sette M, Gandolfo C, Cabano ME, Canovaro P, et al. Prevalence of patent foramen ovale in subjects with obstructive sleep apnea: a transcranial Doppler ultrasound study. Sleep Med. 2003;4(3):219–23.CrossRefPubMed Beelke M, Angeli S, Del Sette M, Gandolfo C, Cabano ME, Canovaro P, et al. Prevalence of patent foramen ovale in subjects with obstructive sleep apnea: a transcranial Doppler ultrasound study. Sleep Med. 2003;4(3):219–23.CrossRefPubMed
47.
go back to reference Sanner BM, Doberauer C, Konermann M, Sturm A, Zidek W. Pulmonary hypertension in patients with obstructive sleep apnea syndrome. Arch Intern Med. 1997;157(21):2483–7.CrossRefPubMed Sanner BM, Doberauer C, Konermann M, Sturm A, Zidek W. Pulmonary hypertension in patients with obstructive sleep apnea syndrome. Arch Intern Med. 1997;157(21):2483–7.CrossRefPubMed
48.
go back to reference Ciccone A, Proserpio P, Roccatagliata DV, Nichelatti M, Gigli GL, Parati G, et al. Wake-up stroke and TIA due to paradoxical embolism during long obstructive sleep apnoeas: a cross-sectional study. Thorax. 2013;68(1):97–104. Ciccone A, Proserpio P, Roccatagliata DV, Nichelatti M, Gigli GL, Parati G, et al. Wake-up stroke and TIA due to paradoxical embolism during long obstructive sleep apnoeas: a cross-sectional study. Thorax. 2013;68(1):97–104.
49.
go back to reference Turkington PM, Bamford J, Wanklyn P, Elliott MW. Prevalence and predictors of upper airway obstruction in the first 24 hours after acute stroke. Stroke. 2002;33:2037–42.CrossRefPubMed Turkington PM, Bamford J, Wanklyn P, Elliott MW. Prevalence and predictors of upper airway obstruction in the first 24 hours after acute stroke. Stroke. 2002;33:2037–42.CrossRefPubMed
50.
go back to reference Iranzo A, Santamaría J, Berenguer J, Sánchez M, Chamorro A. Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction. Neurology. 2002;58(6):911–6.CrossRefPubMed Iranzo A, Santamaría J, Berenguer J, Sánchez M, Chamorro A. Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction. Neurology. 2002;58(6):911–6.CrossRefPubMed
51.
go back to reference • Menon D,S. Sukumaran,R. Varma,A. Radhakrishnan. Impact of obstructive sleep apnea on neurological recovery after ischemic stroke: a prospective study. Acta Neurol Scand. 2017;136(5):419–26. Prospective study of the impact of sleep apnea on neurological recovery after stroke CrossRef • Menon D,S. Sukumaran,R. Varma,A. Radhakrishnan. Impact of obstructive sleep apnea on neurological recovery after ischemic stroke: a prospective study. Acta Neurol Scand. 2017;136(5):419–26. Prospective study of the impact of sleep apnea on neurological recovery after stroke CrossRef
52.
53.
go back to reference Mohsenin V, Valor R. Sleep apnea in patients with hemispheric stroke. Arch Phys Med Rehabil. 1995;76(1):71–6. Mohsenin V, Valor R. Sleep apnea in patients with hemispheric stroke. Arch Phys Med Rehabil. 1995;76(1):71–6.
54.
go back to reference Parra O, Arboix A, Bechich S, García-Eroles L, Montserrat JM, López JA, et al. Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack. Am J Respir Crit Care Med. 2000;161(2 Pt 1):375–80.CrossRefPubMed Parra O, Arboix A, Bechich S, García-Eroles L, Montserrat JM, López JA, et al. Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack. Am J Respir Crit Care Med. 2000;161(2 Pt 1):375–80.CrossRefPubMed
55.
go back to reference Sandberg O, Franklin KA, Bucht G, Gustafson Y. Sleep apnea, delirium, depressed mood, cognition, and ADL ability after stroke. J Am Geriatr Soc. 2001;49(4):391–7.CrossRefPubMed Sandberg O, Franklin KA, Bucht G, Gustafson Y. Sleep apnea, delirium, depressed mood, cognition, and ADL ability after stroke. J Am Geriatr Soc. 2001;49(4):391–7.CrossRefPubMed
56.
go back to reference Kaneko Y, Hajek VE, Zivanovic V, Raboud J, Bradley TD. Relationship of sleep apnea to functional capacity and length of hospitalization following stroke. Sleep. 2003;26(3):293–7.CrossRefPubMed Kaneko Y, Hajek VE, Zivanovic V, Raboud J, Bradley TD. Relationship of sleep apnea to functional capacity and length of hospitalization following stroke. Sleep. 2003;26(3):293–7.CrossRefPubMed
57.
go back to reference Cherkassky T, Oksenberg A, Froom P, Ring H. Sleep-related breathing disorders and rehabilitation outcome of stroke patients: a prospective study. Am J Phys Med Rehabil. 2003;82(6):452–5.PubMed Cherkassky T, Oksenberg A, Froom P, Ring H. Sleep-related breathing disorders and rehabilitation outcome of stroke patients: a prospective study. Am J Phys Med Rehabil. 2003;82(6):452–5.PubMed
58.
go back to reference Ryan CM, Bayley M, Green R, Murray BJ, Bradley TD. Influence of continuous positive airway pressure on outcomes of rehabilitation in stroke patients with obstructive sleep apnea. Stroke. 2011;42(4):1062–7.CrossRefPubMed Ryan CM, Bayley M, Green R, Murray BJ, Bradley TD. Influence of continuous positive airway pressure on outcomes of rehabilitation in stroke patients with obstructive sleep apnea. Stroke. 2011;42(4):1062–7.CrossRefPubMed
59.
go back to reference Bravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, et al. Auto-titrating continuous positive airway pressure for patients with acute transient ischemic attack: a randomized feasibility trial. Stroke. 2010;41:1464–70. Bravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, et al. Auto-titrating continuous positive airway pressure for patients with acute transient ischemic attack: a randomized feasibility trial. Stroke. 2010;41:1464–70.
60.
go back to reference Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011;306(6):613–9. Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011;306(6):613–9.
61.
go back to reference •• Blackwell T, Yaffe K, Laffan A, Redline S, Ancoli-Israel S, Ensrud KE, et al. Osteoporotic fractures in men study group. Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc. 2015;63(3):453–61. Points out the impact of hypoxemia in dementia CrossRefPubMedPubMedCentral •• Blackwell T, Yaffe K, Laffan A, Redline S, Ancoli-Israel S, Ensrud KE, et al. Osteoporotic fractures in men study group. Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc. 2015;63(3):453–61. Points out the impact of hypoxemia in dementia CrossRefPubMedPubMedCentral
62.
go back to reference Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, Shi J, Vitiello MV, Lu L. Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Med Rev 2017 Shi L, Chen SJ, Ma MY, Bao YP, Han Y, Wang YM, Shi J, Vitiello MV, Lu L. Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Med Rev 2017
63.
go back to reference •• Leng Y, McEvoy CT, Allen IE, Yaffe K. Association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis. JAMA Neurol. 2017;74:1237–45. Confirms the growing evidence between sleep apnea and cognitive decline CrossRefPubMedPubMedCentral •• Leng Y, McEvoy CT, Allen IE, Yaffe K. Association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis. JAMA Neurol. 2017;74:1237–45. Confirms the growing evidence between sleep apnea and cognitive decline CrossRefPubMedPubMedCentral
64.
go back to reference Gelber RP, Redline S, Ross GW, Petrovitch H, Sonnen JA, Zarow C, et al. Associations of brain lesions at autopsy with polysomnography features before death. Neurology. 2015;84(3):296–303. Gelber RP, Redline S, Ross GW, Petrovitch H, Sonnen JA, Zarow C, et al. Associations of brain lesions at autopsy with polysomnography features before death. Neurology. 2015;84(3):296–303.
65.
go back to reference • Song TJ, Park JH, Choi KH, Chang Y, Moon J, Kim JH, et al. Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease. Sleep Med. 2017;30:36–42. Adds evidence to the association between sleep apnea and periventricular small vessel disease CrossRefPubMed • Song TJ, Park JH, Choi KH, Chang Y, Moon J, Kim JH, et al. Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease. Sleep Med. 2017;30:36–42. Adds evidence to the association between sleep apnea and periventricular small vessel disease CrossRefPubMed
66.
go back to reference Cho ER, Kim H, Seo HS, Suh S, Lee SK, Shin C. Obstructive sleep apnea as a risk factor for silent cerebral infarction. J Sleep Res. 2013;22(4):452–8.CrossRefPubMed Cho ER, Kim H, Seo HS, Suh S, Lee SK, Shin C. Obstructive sleep apnea as a risk factor for silent cerebral infarction. J Sleep Res. 2013;22(4):452–8.CrossRefPubMed
67.
go back to reference Del Brutto OH, Mera RM, Zambrano M, Castillo PR. Relationship between obstructive sleep apnea and neuroimaging signatures of cerebral small vessel disease in community-dwelling older adults. The Atahualpa Project. Sleep Med. 2017;37:10–2.CrossRefPubMed Del Brutto OH, Mera RM, Zambrano M, Castillo PR. Relationship between obstructive sleep apnea and neuroimaging signatures of cerebral small vessel disease in community-dwelling older adults. The Atahualpa Project. Sleep Med. 2017;37:10–2.CrossRefPubMed
68.
go back to reference Urbano F, Roux F, Schindler J, Mohsenin V. Impaired cerebral autoregulation in obstructive sleep apnea. J Appl Physiol (1985). 2008;105(6):1852–7.CrossRef Urbano F, Roux F, Schindler J, Mohsenin V. Impaired cerebral autoregulation in obstructive sleep apnea. J Appl Physiol (1985). 2008;105(6):1852–7.CrossRef
70.
go back to reference Román GC. Senile dementia of the Binswanger type. A vascular form of dementia in the elderly. JAMA. 1987;258(13):1782–8.CrossRefPubMed Román GC. Senile dementia of the Binswanger type. A vascular form of dementia in the elderly. JAMA. 1987;258(13):1782–8.CrossRefPubMed
71.
go back to reference Moon SY, de Souto Barreto P, Rolland Y, Chupin M, Bouyahia A, Fillon L, et al. Prospective associations between white matter hyperintensities and lower extremity function. Neurology. 2018;90(15):e1291–7. Moon SY, de Souto Barreto P, Rolland Y, Chupin M, Bouyahia A, Fillon L, et al. Prospective associations between white matter hyperintensities and lower extremity function. Neurology. 2018;90(15):e1291–7.
72.
go back to reference Swardfager W, Cogo-Moreira H, Masellis M, Ramírez J, Herrmann N, Edwards JD, et al. The effect of white matter hyperintensities on verbal memory: mediation by temporal lobe atrophy. Neurology. 2018;90(8):e673–82.CrossRefPubMed Swardfager W, Cogo-Moreira H, Masellis M, Ramírez J, Herrmann N, Edwards JD, et al. The effect of white matter hyperintensities on verbal memory: mediation by temporal lobe atrophy. Neurology. 2018;90(8):e673–82.CrossRefPubMed
73.
go back to reference Ramos AR, Gardener H, Rundek T, Elkind MS, Boden-Albala B, Dong C, et al. Sleep disturbances and cognitive decline in the northern Manhattan study. Neurology. 2016;87(14):1511–6.CrossRefPubMedPubMedCentral Ramos AR, Gardener H, Rundek T, Elkind MS, Boden-Albala B, Dong C, et al. Sleep disturbances and cognitive decline in the northern Manhattan study. Neurology. 2016;87(14):1511–6.CrossRefPubMedPubMedCentral
74.
go back to reference Lee S, Shin C. Interaction of obstructive sleep apnoea and cognitive impairment with slow gait speed in middle-aged and older adults. Age Ageing. 2017;46(4):653–9.PubMed Lee S, Shin C. Interaction of obstructive sleep apnoea and cognitive impairment with slow gait speed in middle-aged and older adults. Age Ageing. 2017;46(4):653–9.PubMed
75.
go back to reference Baillieul S, Wuyam B, Pépin JL, Marillier M, Tamisier R, Pérennou D, et al. Continuous positive airway pressure improves gait control in severe obstructive sleep apnoea: a prospective study. PLoS One. 2018;13(2):e0192442. Baillieul S, Wuyam B, Pépin JL, Marillier M, Tamisier R, Pérennou D, et al. Continuous positive airway pressure improves gait control in severe obstructive sleep apnoea: a prospective study. PLoS One. 2018;13(2):e0192442.
76.
go back to reference Kohler M et al. Effect of CPAP on stroke risk factors and stroke. In: Culebras A, editor. Sleep, stroke and cardiovascular disease. Cambridge University Press; 2013. p. 115. Kohler M et al. Effect of CPAP on stroke risk factors and stroke. In: Culebras A, editor. Sleep, stroke and cardiovascular disease. Cambridge University Press; 2013. p. 115.
77.
go back to reference Walia HK, Griffith SD, Foldvary-Schaefer N, Thomas G, Bravo EL, Moul DE, et al. Longitudinal effect of CPAP on BP in resistant and nonresistant hypertension in a large clinic-based cohort. Chest. 2016;149(3):747–55. Walia HK, Griffith SD, Foldvary-Schaefer N, Thomas G, Bravo EL, Moul DE, et al. Longitudinal effect of CPAP on BP in resistant and nonresistant hypertension in a large clinic-based cohort. Chest. 2016;149(3):747–55.
78.
go back to reference Iftikhar IH, Valentine CW, Bittencourt LR, et al. Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. J Hypertens. 2014;32(12):2341–50.CrossRefPubMedPubMedCentral Iftikhar IH, Valentine CW, Bittencourt LR, et al. Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. J Hypertens. 2014;32(12):2341–50.CrossRefPubMedPubMedCentral
79.
go back to reference Martínez-García MA, Gómez-Aldaraví R, Soler-Cataluña JJ, Martínez TG, Bernácer-Alpera B, Román-Sánchez P. Positive effect of CPAP treatment on the control of difficult-to-treat hypertension. Eur Respir J. 2007;29:951–7.CrossRefPubMed Martínez-García MA, Gómez-Aldaraví R, Soler-Cataluña JJ, Martínez TG, Bernácer-Alpera B, Román-Sánchez P. Positive effect of CPAP treatment on the control of difficult-to-treat hypertension. Eur Respir J. 2007;29:951–7.CrossRefPubMed
80.
go back to reference Martínez-García MA, Soler-Cataluña JJ, Ejarque-Martínez L, Soriano Y, Román-Sánchez P, Illa FB, et al. Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study. Am J Respir Crit Care Med. 2009;180(1):36–41.CrossRefPubMed Martínez-García MA, Soler-Cataluña JJ, Ejarque-Martínez L, Soriano Y, Román-Sánchez P, Illa FB, et al. Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study. Am J Respir Crit Care Med. 2009;180(1):36–41.CrossRefPubMed
81.
go back to reference Gupta A, Shukla G, Afsar M, Poornima S, Pandey RM, Goyal V, et al. Role of positive airway pressure therapy for obstructive sleep apnea in patients with stroke: a randomized controlled trial. J Clin Sleep Med. 2018;14:511–21. Gupta A, Shukla G, Afsar M, Poornima S, Pandey RM, Goyal V, et al. Role of positive airway pressure therapy for obstructive sleep apnea in patients with stroke: a randomized controlled trial. J Clin Sleep Med. 2018;14:511–21.
82.
go back to reference •• Brill AK, Horvath T, Seiler A, Camilo M, Haynes AG, Ott SR, et al. CPAP as treatment of sleep apnea after stroke: a meta-analysis of randomized trials. Neurology. 2018;90(14):e1222–30. Treatment of sleep apnea may reduce progression of cerebrovascular complications •• Brill AK, Horvath T, Seiler A, Camilo M, Haynes AG, Ott SR, et al. CPAP as treatment of sleep apnea after stroke: a meta-analysis of randomized trials. Neurology. 2018;90(14):e1222–30. Treatment of sleep apnea may reduce progression of cerebrovascular complications
83.
go back to reference McEvoy RD, Antic NA, Heeley E, Luo Y, Ou Q, Zhang X, et al. SAVE investigators and coordinators. CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med. 2016;375(10):919–31. McEvoy RD, Antic NA, Heeley E, Luo Y, Ou Q, Zhang X, et al. SAVE investigators and coordinators. CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med. 2016;375(10):919–31.
84.
go back to reference Stenzel-Poore MP, Stevens SL, King JS, Simon RP. Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke. 2007;38(2 Suppl):680–5. ReviewCrossRefPubMed Stenzel-Poore MP, Stevens SL, King JS, Simon RP. Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke. 2007;38(2 Suppl):680–5. ReviewCrossRefPubMed
Metadata
Title
Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia
Authors
Antonio Culebras
Sanam Anwar
Publication date
01-08-2018
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 8/2018
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-018-0855-1

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