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Open Access 01-04-2016 | Short Communication

Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid

Authors: Nina Jensen, Jacob Kwasi Autzen, Lene Pedersen

Published in: Neurogenetics | Issue 2/2016

Abstract

Mutations in the SLC20A2-gene encoding the inorganic phosphate (Pi) transporter PiT2 can explain approximately 40 % of the familial cases of the rare neurodegenerative disorder primary familial brain calcification (Fahr’s disease). The disease characteristic, cerebrovascular-associated calcifications, is also present in Slc20a2-knockout (KO) mice. Little is known about the specific role(s) of PiT2 in the brain. Recent in vitro studies, however, suggest a role in regulation of the [Pi] in cerebrospinal fluid (CSF). We here show that Slc20a2-KO mice indeed have a high CSF [Pi] in agreement with a role of PiT2 in Pi export from the CSF. The implications in relation to disease mechanism are discussed.

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Title: Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid
Authors: Nina Jensen
Jacob Kwasi Autzen
Lene Pedersen
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Neurogenetics / Issue 2/2016
Print ISSN: 1364-6745
Electronic ISSN: 1364-6753
DOI: https://doi.org/10.1007/s10048-015-0469-6

2024 ASCO Annual Meeting

Springer Medicine

Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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