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Published in: Clinical and Translational Oncology 12/2017

Open Access 01-12-2017 | Review Article

SLC14A1: a novel target for human urothelial cancer

Authors: R. Hou, X. Kong, B. Yang, Y. Xie, G. Chen

Published in: Clinical and Translational Oncology | Issue 12/2017

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Abstract

Urinary bladder cancer is the second commonly diagnosed genitourinary malignancy. Previously, bio-molecular alterations have been observed within certain locations such as chromosome 9, retinoblastoma gene and fibroblast growth factor receptor-3. Solute carrier family 14 member 1 (SLC14A1) gene encodes the type-B urea transporter (UT-B) which facilitates the passive movement of urea across cell membrane, and has recently been related with human malignancies, especially for bladder cancer. Herein, we discussed the SLC14A1 gene and UT-B protein properties, aiming to elucidate the expression behavior of SLC14A1 in human bladder cancer. Furthermore, by reviewing some well-established theories regarding the carcinogenesis of bladder cancer, including several genome wide association researches, we have bridged the mechanisms of cancer development with the aberrant expression of SLC14A1. In conclusion, the altered expression of SLC14A1 gene in human urothelial cancer may implicate its significance as a novel target for research.
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Metadata
Title
SLC14A1: a novel target for human urothelial cancer
Authors
R. Hou
X. Kong
B. Yang
Y. Xie
G. Chen
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
Clinical and Translational Oncology / Issue 12/2017
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-017-1693-3

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