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Acta Neuropathologica
Published in: Acta Neuropathologica 2/2009

01-08-2009 | Correspondence

Skin metastases of glioblastoma in the absence of intracranial progression are associated with a shift towards a mesenchymal immunophenotype: report of two cases

Authors: Rebecca Senetta, Elisa Trevisan, Roberta Rudà, Franco Benech, Riccardo Soffietti, Paola Cassoni

Published in: Acta Neuropathologica | Issue 2/2009

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Excerpt

Glioblastoma multiforme (GBM) is the most malignant astrocytic tumour. Extra-neural spread is exceedingly rare, and usually develops at the time of intracranial progression following a surgical procedure [2‐4]. Less frequently, metastases are a consequence of spontaneous tumour trans-dural extension or haematogenous spread. Here, we describe two unusual cases of GBM in which scalp metastases appeared in the absence of intracranial disease progression. …
Literature
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Burger PC, Mahley MS Jr, Dudka L, Vogel FS (1979) The morphologic effects of radiation administered therapeutically for intracranial gliomas. A post-mortem study of 25 cases. Cancer 44:1256–1272PubMedCrossRef
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Figueroa P, Lupton JR, Remington T et al (2002) Cutaneous metastasis from an intracranial glioblastoma multiforme. J Am Acad Dermatol 46:297–300PubMedCrossRef
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Jain N, Mirakhur M, Flynn P, Choudhari A (2005) Cutaneous metastasis from glioblastoma. Br J Neurosurg 19:65–68PubMedCrossRef
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Mentrikoski M, Johnson MD, Korones DN, Scott GA (2008) Glioblastoma multiforme in skin: a report of 2 cases and review of the literature. Am J Dermatopathol 30:381–384PubMedCrossRef
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Paulus W, Huettner C, Tonn JC (1994) Collagens, integrins and the mesenchymal drift in glioblastomas: a comparison of biopsy specimens, spheroid and early monolayer cultures. Int J Cancer 15;58:841–846
Metadata
Title
Skin metastases of glioblastoma in the absence of intracranial progression are associated with a shift towards a mesenchymal immunophenotype: report of two cases
Authors
Rebecca Senetta
Elisa Trevisan
Roberta Rudà
Franco Benech
Riccardo Soffietti
Paola Cassoni
Publication date
01-08-2009
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 2/2009
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-009-0543-y

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