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Critical Care
Published in: Critical Care 1/2017

Open Access 01-12-2017 | Letter

Skin autofluorescence in acute kidney injury

Authors: Aurelie Lavielle, Sebastien Rubin, Alexandre Boyer, Karine Moreau, Kalina Rajaobelina, Christian Combe, Vincent Rigalleau

Published in: Critical Care | Issue 1/2017

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Excerpt

We were interested by the article from De Corte et al. about the poor long-term outcome after acute kidney injury (AKI) [1]. Besides initial oliguria, the three predictors for dialysis dependence were age, diabetes, and chronic kidney disease (CKD), which have previously been related to the accumulation of advanced glycation end-products (AGEs) as evaluated by skin autofluorescence (sAF). sAF is an indirect marker that has been related to the skin concentrations of fluorescent (pentosidine) and non-fluorescent AGEs (carboxy-methyl-lysine and carboxy-ethyl-lysine) in skin biopsies of hemodialized subjects [2]. Could sAF be altered in AKI? …
Literature
1.
De Corte W, Dhondt A, Vanholder R, De Waele J, Decruyenaere J, Sergoyne V, et al. Long-term outcome in ICU patients with acute kidney injury treated with renal replacement therapy: a prospective cohort study. Crit Care. 2016;20:256.CrossRefPubMedPubMedCentral
2.
Meerwaldt RR, Hartog JWL, Graaff R, Huisman RJ, Links TP, den Hollander RC, et al. Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. J Am Soc Nephrol. 2005;16:3687–93.CrossRefPubMed
3.
Koetsier M, Lutgers HL, de Jonge C, Links TP, Smit AJ, Graaff R. Reference values of skin autofluorescence. Diabetes Technol Ther. 2010;12:399–403
4.
Rajaobelina K, Cougnard-Grégoire A, Delcourt C, Gin H, Barberger-Gateau P, Rigalleau V. Autofluorescence of skin advanced glycation end products: marker of metabolic memory in the elderly population. J Gerontol A Biol Sci Med Sci. 2015;70:841–6.CrossRefPubMed
5.
Sebekova K, Blazicek P, Syrova D, Krivosikova Z, Spustova V, Heidland A, et al. Circulating advanced glycation end product levels in rats rapidly increase with acute renal failure. Kidney Int Suppl. 2001;78:S58–62.CrossRefPubMed
6.
Greven WL, Smit JM, Rommes JH, Spronk PE. Accumulation of advanced glycation end (AGEs) products in intensive care patients: an observational, prospective study. BMC Clin Pathol. 2010;10:4.CrossRefPubMedPubMedCentral
Metadata
Title
Skin autofluorescence in acute kidney injury
Authors
Aurelie Lavielle
Sebastien Rubin
Alexandre Boyer
Karine Moreau
Kalina Rajaobelina
Christian Combe
Vincent Rigalleau
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2017
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-017-1598-0

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