Skip to main content
Top
Published in: Journal of Cardiothoracic Surgery 1/2007

Open Access 01-12-2007 | Review

Skeletonization of radial and gastroepiploic conduits in coronary artery bypass surgery

Authors: Rachel M Massey, Oliver J Warren, Michal Szczeklik, Sophie Wallace, Daniel R Leff, John Kokotsakis, Ara Darzi, Thanos Athanasiou

Published in: Journal of Cardiothoracic Surgery | Issue 1/2007

Login to get access

Abstract

The use of a skeletonized internal thoracic artery in coronary artery bypass graft surgery has been shown to confer certain advantages over a traditional pedicled technique, particularly in certain patient groups. Recent reports indicate that radial and gastroepiploic arteries can also be harvested using a skeletonized technique. The aim of this study is to systematically review the available evidence regarding the use of skeletonized radial and gastroepiploic arteries within coronary artery bypass surgery, focusing specifically on it's effect on conduit length and flow, levels of endothelial damage, graft patency and clinical outcome. Four electronic databases were systematically searched for studies reporting the utilisation of the skeletonization technique within coronary revascularisation surgery in humans. Reference lists of all identified studies were checked for any missing publications. There appears to be some evidence that skeletonization may improve angiographic patency, when compared with pedicled vessels in the short to mid-term. We have found no suggestion of increased complication rates or increased operating time. Skeletonization may increase the length of the conduit, and the number of sequential graft sites, but no clear clinical benefits are apparent. Our study suggests that there is not enough high quality or consistent evidence to currently advocate the application of this technique to radial or gastroepiploic conduits ahead of a traditional pedicled technique.
Appendix
Available only for authorised users
Literature
1.
2.
go back to reference Athanasiou T, Crossman MC, Asimakopoulos G, Cherian A, Weerasinghe A, Glenville B, Casula R: Should the internal thoracic artery be skeletonized?. Ann Thorac Surg. 2004, 77 (6): 2238-2246. 10.1016/j.athoracsur.2003.10.041.CrossRefPubMed Athanasiou T, Crossman MC, Asimakopoulos G, Cherian A, Weerasinghe A, Glenville B, Casula R: Should the internal thoracic artery be skeletonized?. Ann Thorac Surg. 2004, 77 (6): 2238-2246. 10.1016/j.athoracsur.2003.10.041.CrossRefPubMed
3.
go back to reference Ryu SW, Ahn BH, Choo SJ, Na KJ, Ahn YK, Jeong MH, Kim SH: Skeletonized gastroepiploic artery as a composite graft for total arterial revascularization. Ann Thorac Surg. 2005, 80 (1): 118-123. 10.1016/j.athoracsur.2005.02.008.CrossRefPubMed Ryu SW, Ahn BH, Choo SJ, Na KJ, Ahn YK, Jeong MH, Kim SH: Skeletonized gastroepiploic artery as a composite graft for total arterial revascularization. Ann Thorac Surg. 2005, 80 (1): 118-123. 10.1016/j.athoracsur.2005.02.008.CrossRefPubMed
4.
go back to reference Carpentier A, Guermonprez JL, Deloche A, Frechette C, DuBost C: The aorta-to-coronary radial artery bypass graft. A technique avoiding pathological changes in grafts. Ann Thorac Surg. 1973, 16 (2): 111-121.CrossRefPubMed Carpentier A, Guermonprez JL, Deloche A, Frechette C, DuBost C: The aorta-to-coronary radial artery bypass graft. A technique avoiding pathological changes in grafts. Ann Thorac Surg. 1973, 16 (2): 111-121.CrossRefPubMed
5.
go back to reference Acar C, Jebara VA, Portoghese M, Beyssen B, Pagny JY, Grare P, Chachques JC, Fabiani JN, Deloche A, Guermonprez JL: Revival of the radial artery for coronary artery bypass grafting. Ann Thorac Surg. 1992, 54 (4): 652-9; discussion 659-60.CrossRefPubMed Acar C, Jebara VA, Portoghese M, Beyssen B, Pagny JY, Grare P, Chachques JC, Fabiani JN, Deloche A, Guermonprez JL: Revival of the radial artery for coronary artery bypass grafting. Ann Thorac Surg. 1992, 54 (4): 652-9; discussion 659-60.CrossRefPubMed
6.
go back to reference Pym J, Brown P, Pearson M, Parker J: Right gastroepiploic-to-coronary artery bypass. The first decade of use. Circulation. 1995, 92 (9 Suppl): II45-9.CrossRefPubMed Pym J, Brown P, Pearson M, Parker J: Right gastroepiploic-to-coronary artery bypass. The first decade of use. Circulation. 1995, 92 (9 Suppl): II45-9.CrossRefPubMed
7.
go back to reference van Son JA, Smedts F, Vincent JG, van Lier HJ, Kubat K: Comparative anatomic studies of various arterial conduits for myocardial revascularization. J Thorac Cardiovasc Surg. 1990, 99 (4): 703-707.PubMed van Son JA, Smedts F, Vincent JG, van Lier HJ, Kubat K: Comparative anatomic studies of various arterial conduits for myocardial revascularization. J Thorac Cardiovasc Surg. 1990, 99 (4): 703-707.PubMed
9.
go back to reference Chardigny C, Jebara VA, Acar C, Descombes JJ, Verbeuren TJ, Carpentier A, Fabiani JN: Vasoreactivity of the radial artery. Comparison with the internal mammary and gastroepiploic arteries with implications for coronary artery surgery. Circulation. 1993, 88 (5 Pt 2): II115-27.PubMed Chardigny C, Jebara VA, Acar C, Descombes JJ, Verbeuren TJ, Carpentier A, Fabiani JN: Vasoreactivity of the radial artery. Comparison with the internal mammary and gastroepiploic arteries with implications for coronary artery surgery. Circulation. 1993, 88 (5 Pt 2): II115-27.PubMed
10.
go back to reference Hirose H, Amano A, Takahashi A: Minimally invasive direct coronary artery bypass: current experience. Heart Surg Forum. 2003, 6 (6): E129-32.PubMed Hirose H, Amano A, Takahashi A: Minimally invasive direct coronary artery bypass: current experience. Heart Surg Forum. 2003, 6 (6): E129-32.PubMed
11.
go back to reference Watanabe G, Takemura H, Tomita S, Nagamine H, Kamiya H, Kanamori T: Skeletonized radial artery graft with the St. Jude Medical Symmetry Bypass System (aortic connector system). Ann Thorac Surg. 2004, 77 (5): 1550-2; discussion 1552. 10.1016/j.athoracsur.2003.10.012.CrossRefPubMed Watanabe G, Takemura H, Tomita S, Nagamine H, Kamiya H, Kanamori T: Skeletonized radial artery graft with the St. Jude Medical Symmetry Bypass System (aortic connector system). Ann Thorac Surg. 2004, 77 (5): 1550-2; discussion 1552. 10.1016/j.athoracsur.2003.10.012.CrossRefPubMed
12.
go back to reference Amano A, Takahashi A, Hirose H: Skeletonized radial artery grafting: improved angiographic results. Ann Thorac Surg. 2002, 73 (6): 1880-1887. 10.1016/S0003-4975(02)03559-2.CrossRefPubMed Amano A, Takahashi A, Hirose H: Skeletonized radial artery grafting: improved angiographic results. Ann Thorac Surg. 2002, 73 (6): 1880-1887. 10.1016/S0003-4975(02)03559-2.CrossRefPubMed
13.
go back to reference Kamiya H, Watanabe G, Takemura H, Tomita S, Nagamine H, Kanamori T: Total arterial revascularization with composite skeletonized gastroepiploic artery graft in off-pump coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2004, 127 (4): 1151-1157. 10.1016/j.jtcvs.2003.09.057.CrossRefPubMed Kamiya H, Watanabe G, Takemura H, Tomita S, Nagamine H, Kanamori T: Total arterial revascularization with composite skeletonized gastroepiploic artery graft in off-pump coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2004, 127 (4): 1151-1157. 10.1016/j.jtcvs.2003.09.057.CrossRefPubMed
14.
go back to reference Gagliardotto P, Coste P, Lazreg M, Dor V: Skeletonized right gastroepiploic artery used for coronary artery bypass grafting. Ann Thorac Surg. 1998, 66 (1): 240-242. 10.1016/S0003-4975(98)00403-2.CrossRefPubMed Gagliardotto P, Coste P, Lazreg M, Dor V: Skeletonized right gastroepiploic artery used for coronary artery bypass grafting. Ann Thorac Surg. 1998, 66 (1): 240-242. 10.1016/S0003-4975(98)00403-2.CrossRefPubMed
15.
go back to reference Taggart DP, Mathur MN, Ahmad I: Skeletonization of the radial artery: advantages over the pedicled technique. Ann Thorac Surg. 2001, 72 (1): 298-299. 10.1016/S0003-4975(00)02699-0.CrossRefPubMed Taggart DP, Mathur MN, Ahmad I: Skeletonization of the radial artery: advantages over the pedicled technique. Ann Thorac Surg. 2001, 72 (1): 298-299. 10.1016/S0003-4975(00)02699-0.CrossRefPubMed
16.
go back to reference Guyton AC, Hall JE: Textbook of medical physiology. 2000, Philadelphia , WB Saunders Co., 726-727. Guyton AC, Hall JE: Textbook of medical physiology. 2000, Philadelphia , WB Saunders Co., 726-727.
17.
go back to reference Aneman A, Eisenhofer G, Olbe L, Dalenback J, Nitescu P, Fandriks L, Friberg P: Sympathetic discharge to mesenteric organs and the liver. Evidence for substantial mesenteric organ norepinephrine spillover. J Clin Invest. 1996, 97 (7): 1640-1646.CrossRefPubMedPubMedCentral Aneman A, Eisenhofer G, Olbe L, Dalenback J, Nitescu P, Fandriks L, Friberg P: Sympathetic discharge to mesenteric organs and the liver. Evidence for substantial mesenteric organ norepinephrine spillover. J Clin Invest. 1996, 97 (7): 1640-1646.CrossRefPubMedPubMedCentral
18.
go back to reference Amano A, Li R, Hirose H: Off-Pump Coronary Artery Bypass Using Skeletonized Gastroepiploic Artery, a Pilot Study. Heart Surg Forum. 2004, 7 (1): 101-104.CrossRefPubMed Amano A, Li R, Hirose H: Off-Pump Coronary Artery Bypass Using Skeletonized Gastroepiploic Artery, a Pilot Study. Heart Surg Forum. 2004, 7 (1): 101-104.CrossRefPubMed
19.
go back to reference Asai T, Tabata S: Skeletonization of the right gastroepiploic artery using an ultrasonic scalpel. Ann Thorac Surg. 2002, 74 (5): 1715-1717. 10.1016/S0003-4975(02)03765-7.CrossRefPubMed Asai T, Tabata S: Skeletonization of the right gastroepiploic artery using an ultrasonic scalpel. Ann Thorac Surg. 2002, 74 (5): 1715-1717. 10.1016/S0003-4975(02)03765-7.CrossRefPubMed
20.
go back to reference Li R, Amano A, Miyagawa H, Dohi S, Hayashi I, Kajimoto K, Shimada A, Hirose H: Skeletonized gastroepiploic artery for off-pump coronary artery bypass grafting. Heart Surg Forum. 2004, 7 (2): E164-9. 10.1532/HSF98.20033004.CrossRefPubMed Li R, Amano A, Miyagawa H, Dohi S, Hayashi I, Kajimoto K, Shimada A, Hirose H: Skeletonized gastroepiploic artery for off-pump coronary artery bypass grafting. Heart Surg Forum. 2004, 7 (2): E164-9. 10.1532/HSF98.20033004.CrossRefPubMed
21.
go back to reference Rukosujew A, Reichelt R, Fabricius AM, Drees G, Tjan TD, Rothenburger M, Hoffmeier A, Scheld HH, Schmid C: Skeletonization versus pedicle preparation of the radial artery with and without the ultrasonic scalpel. Ann Thorac Surg. 2004, 77 (1): 120-125. 10.1016/S0003-4975(03)01488-7.CrossRefPubMed Rukosujew A, Reichelt R, Fabricius AM, Drees G, Tjan TD, Rothenburger M, Hoffmeier A, Scheld HH, Schmid C: Skeletonization versus pedicle preparation of the radial artery with and without the ultrasonic scalpel. Ann Thorac Surg. 2004, 77 (1): 120-125. 10.1016/S0003-4975(03)01488-7.CrossRefPubMed
22.
go back to reference Hirose H, Amano A: Skeletonized radial artery grafting: one-year patency rate. Heart Surg Forum. 2004, 7 (4): E277-82. 10.1532/HSF98.20041017.CrossRefPubMed Hirose H, Amano A: Skeletonized radial artery grafting: one-year patency rate. Heart Surg Forum. 2004, 7 (4): E277-82. 10.1532/HSF98.20041017.CrossRefPubMed
23.
go back to reference Kamiya H, Watanabe G, Takemura H, Tomita S, Nagamine H, Kanamori T: Skeletonization of gastroepiploic artery graft in off-pump coronary artery bypass grafting: early clinical and angiographic assessment. Ann Thorac Surg. 2004, 77 (6): 2046-2050. 10.1016/j.athoracsur.2003.10.101.CrossRefPubMed Kamiya H, Watanabe G, Takemura H, Tomita S, Nagamine H, Kanamori T: Skeletonization of gastroepiploic artery graft in off-pump coronary artery bypass grafting: early clinical and angiographic assessment. Ann Thorac Surg. 2004, 77 (6): 2046-2050. 10.1016/j.athoracsur.2003.10.101.CrossRefPubMed
24.
go back to reference Kamiya H, Watanabe G, Tomita S, Takemura H, Nagamine H, Nishida S: The technical aspect of the gastroepiploic artery graft skeletonization with the harmonic scalpel: the samurai technique. Heart Surg Forum. 2005, 8 (2): E121-3.CrossRefPubMed Kamiya H, Watanabe G, Tomita S, Takemura H, Nagamine H, Nishida S: The technical aspect of the gastroepiploic artery graft skeletonization with the harmonic scalpel: the samurai technique. Heart Surg Forum. 2005, 8 (2): E121-3.CrossRefPubMed
25.
go back to reference Fukata Y, Horike K, Kano M: Histological study on the influences of an ultrasonic scalpel on skeletonized vessel wall. Ann Thorac Cardiovasc Surg. 2002, 8 (5): 291-297.PubMed Fukata Y, Horike K, Kano M: Histological study on the influences of an ultrasonic scalpel on skeletonized vessel wall. Ann Thorac Cardiovasc Surg. 2002, 8 (5): 291-297.PubMed
26.
go back to reference Weinschelbaum EE, Macchia A, Caramutti VM, Machain HA, Raffaelli HA, Favaloro MR, Favaloro RR, Dulbecco EA, Abud JA, De Laurentiis M, Gabe ED: Myocardial revascularization with radial and mammary arteries: initial and mid-term results. Ann Thorac Surg. 2000, 70 (4): 1378-1383. 10.1016/S0003-4975(00)01701-X.CrossRefPubMed Weinschelbaum EE, Macchia A, Caramutti VM, Machain HA, Raffaelli HA, Favaloro MR, Favaloro RR, Dulbecco EA, Abud JA, De Laurentiis M, Gabe ED: Myocardial revascularization with radial and mammary arteries: initial and mid-term results. Ann Thorac Surg. 2000, 70 (4): 1378-1383. 10.1016/S0003-4975(00)01701-X.CrossRefPubMed
27.
go back to reference Acar C, Ramsheyi A, Pagny JY, Jebara V, Barrier P, Fabiani JN, Deloche A, Guermonprez JL, Carpentier A: The radial artery for coronary artery bypass grafting: clinical and angiographic results at five years. J Thorac Cardiovasc Surg. 1998, 116 (6): 981-989. 10.1016/S0022-5223(98)70050-9.CrossRefPubMed Acar C, Ramsheyi A, Pagny JY, Jebara V, Barrier P, Fabiani JN, Deloche A, Guermonprez JL, Carpentier A: The radial artery for coronary artery bypass grafting: clinical and angiographic results at five years. J Thorac Cardiovasc Surg. 1998, 116 (6): 981-989. 10.1016/S0022-5223(98)70050-9.CrossRefPubMed
28.
go back to reference Fitzgibbon GM, Kafka HP, Leach AJ, Keon WJ, Hooper GD, Burton JR: Coronary bypass graft fate and patient outcome: angiographic follow-up of 5,065 grafts related to survival and reoperation in 1,388 patients during 25 years. J Am Coll Cardiol. 1996, 28 (3): 616-626. 10.1016/0735-1097(96)00206-9.CrossRefPubMed Fitzgibbon GM, Kafka HP, Leach AJ, Keon WJ, Hooper GD, Burton JR: Coronary bypass graft fate and patient outcome: angiographic follow-up of 5,065 grafts related to survival and reoperation in 1,388 patients during 25 years. J Am Coll Cardiol. 1996, 28 (3): 616-626. 10.1016/0735-1097(96)00206-9.CrossRefPubMed
29.
go back to reference Gaudino M, Nasso G, Canosa C, Glieca F, Salica A, Alessandrini F, Possati G: Midterm angiographic patency and vasoreactive profile of proximal versus distal radial artery grafts. Ann Thorac Surg. 2005, 79 (6): 1987-1989. 10.1016/j.athoracsur.2005.01.003.CrossRefPubMed Gaudino M, Nasso G, Canosa C, Glieca F, Salica A, Alessandrini F, Possati G: Midterm angiographic patency and vasoreactive profile of proximal versus distal radial artery grafts. Ann Thorac Surg. 2005, 79 (6): 1987-1989. 10.1016/j.athoracsur.2005.01.003.CrossRefPubMed
30.
go back to reference Myocardial infarction and mortality in the coronary artery surgery study (CASS) randomized trial. N Engl J Med. 1984, 310 (12): 750-758. Myocardial infarction and mortality in the coronary artery surgery study (CASS) randomized trial. N Engl J Med. 1984, 310 (12): 750-758.
31.
go back to reference Ellozy SH, Harris MT, Bauer JJ, Gorfine SR, Kreel I: Early postoperative small-bowel obstruction: a prospective evaluation in 242 consecutive abdominal operations. Dis Colon Rectum. 2002, 45 (9): 1214-1217. 10.1007/s10350-004-6395-6.CrossRefPubMed Ellozy SH, Harris MT, Bauer JJ, Gorfine SR, Kreel I: Early postoperative small-bowel obstruction: a prospective evaluation in 242 consecutive abdominal operations. Dis Colon Rectum. 2002, 45 (9): 1214-1217. 10.1007/s10350-004-6395-6.CrossRefPubMed
32.
go back to reference Israelsson LA, Jonsson T: Incisional hernia after midline laparotomy: a prospective study. Eur J Surg. 1996, 162 (2): 125-129.PubMed Israelsson LA, Jonsson T: Incisional hernia after midline laparotomy: a prospective study. Eur J Surg. 1996, 162 (2): 125-129.PubMed
33.
go back to reference Mack MJ: Minimally invasive cardiac surgery. Surg Endosc. 2006, 20 Suppl 2: S488-92. 10.1007/s00464-006-0110-8.CrossRefPubMed Mack MJ: Minimally invasive cardiac surgery. Surg Endosc. 2006, 20 Suppl 2: S488-92. 10.1007/s00464-006-0110-8.CrossRefPubMed
34.
go back to reference Tedoriya T, Kawasuji M, Sakakibara N, Ueyama K, Watanabe Y: Pressure characteristics in arterial grafts for coronary bypass surgery. Cardiovasc Surg. 1995, 3 (4): 381-385. 10.1016/0967-2109(95)94155-P.CrossRefPubMed Tedoriya T, Kawasuji M, Sakakibara N, Ueyama K, Watanabe Y: Pressure characteristics in arterial grafts for coronary bypass surgery. Cardiovasc Surg. 1995, 3 (4): 381-385. 10.1016/0967-2109(95)94155-P.CrossRefPubMed
35.
go back to reference Ochi M, Hatori N, Fujii M, Saji Y, Tanaka S, Honma H: Limited flow capacity of the right gastroepiploic artery graft: postoperative echocardiographic and angiographic evaluation. Ann Thorac Surg. 2001, 71 (4): 1210-1214. 10.1016/S0003-4975(00)02681-3.CrossRefPubMed Ochi M, Hatori N, Fujii M, Saji Y, Tanaka S, Honma H: Limited flow capacity of the right gastroepiploic artery graft: postoperative echocardiographic and angiographic evaluation. Ann Thorac Surg. 2001, 71 (4): 1210-1214. 10.1016/S0003-4975(00)02681-3.CrossRefPubMed
36.
37.
go back to reference Gaudino M, Toesca A, Nori SL, Glieca F, Possati G: Effect of skeletonization of the internal thoracic artery on vessel wall integrity. Ann Thorac Surg. 1999, 68 (5): 1623-1627. 10.1016/S0003-4975(99)00664-5.CrossRefPubMed Gaudino M, Toesca A, Nori SL, Glieca F, Possati G: Effect of skeletonization of the internal thoracic artery on vessel wall integrity. Ann Thorac Surg. 1999, 68 (5): 1623-1627. 10.1016/S0003-4975(99)00664-5.CrossRefPubMed
38.
go back to reference Ueda T, Taniguchi S, Kawata T, Mizuguchi K, Nakajima M, Yoshioka A: Does skeletonization compromise the integrity of internal thoracic artery grafts?. Ann Thorac Surg. 2003, 75 (5): 1429-1433. 10.1016/S0003-4975(02)04893-2.CrossRefPubMed Ueda T, Taniguchi S, Kawata T, Mizuguchi K, Nakajima M, Yoshioka A: Does skeletonization compromise the integrity of internal thoracic artery grafts?. Ann Thorac Surg. 2003, 75 (5): 1429-1433. 10.1016/S0003-4975(02)04893-2.CrossRefPubMed
39.
go back to reference Boodhwani M, Lam BK, Nathan HJ, Mesana TG, Ruel M, Zeng W, Sellke FW, Rubens FD: Skeletonized internal thoracic artery harvest reduces pain and dysesthesia and improves sternal perfusion after coronary artery bypass surgery: a randomized, double-blind, within-patient comparison. Circulation. 2006, 114 (8): 766-773. 10.1161/CIRCULATIONAHA.106.615427.CrossRefPubMed Boodhwani M, Lam BK, Nathan HJ, Mesana TG, Ruel M, Zeng W, Sellke FW, Rubens FD: Skeletonized internal thoracic artery harvest reduces pain and dysesthesia and improves sternal perfusion after coronary artery bypass surgery: a randomized, double-blind, within-patient comparison. Circulation. 2006, 114 (8): 766-773. 10.1161/CIRCULATIONAHA.106.615427.CrossRefPubMed
40.
go back to reference Matsumoto K, Tsuneyoshi I, Iguro Y, Kinjo T, Yotsumoto G, Ueno M, Kanmura Y, Sakata R: Effects of ultrasonic skeletonization on internal thoracic and gastroepiploic arteries for coronary artery bypass grafting. Eur J Cardiothorac Surg. 2006, 30 (4): 592-596. 10.1016/j.ejcts.2006.07.024.CrossRefPubMed Matsumoto K, Tsuneyoshi I, Iguro Y, Kinjo T, Yotsumoto G, Ueno M, Kanmura Y, Sakata R: Effects of ultrasonic skeletonization on internal thoracic and gastroepiploic arteries for coronary artery bypass grafting. Eur J Cardiothorac Surg. 2006, 30 (4): 592-596. 10.1016/j.ejcts.2006.07.024.CrossRefPubMed
41.
go back to reference Brown P, Brunnhuber K, Chalkidou K, Chalmers I, Clarke M, Fenton M, Forbes C, Glanville J, Hicks NJ, Moody J, Twaddle S, Timimi H, Young P: How to formulate research recommendations. Bmj. 2006, 333 (7572): 804-806. 10.1136/bmj.38987.492014.94.CrossRefPubMedPubMedCentral Brown P, Brunnhuber K, Chalkidou K, Chalmers I, Clarke M, Fenton M, Forbes C, Glanville J, Hicks NJ, Moody J, Twaddle S, Timimi H, Young P: How to formulate research recommendations. Bmj. 2006, 333 (7572): 804-806. 10.1136/bmj.38987.492014.94.CrossRefPubMedPubMedCentral
Metadata
Title
Skeletonization of radial and gastroepiploic conduits in coronary artery bypass surgery
Authors
Rachel M Massey
Oliver J Warren
Michal Szczeklik
Sophie Wallace
Daniel R Leff
John Kokotsakis
Ara Darzi
Thanos Athanasiou
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2007
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/1749-8090-2-26

Other articles of this Issue 1/2007

Journal of Cardiothoracic Surgery 1/2007 Go to the issue