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Virchows Archiv
Published in: Virchows Archiv 1/2007

01-08-2007 | Review and Perspective

Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors

Authors: Günter Klöppel, Guido Rindi, Martin Anlauf, Aurel Perren, Paul Komminoth

Published in: Virchows Archiv | Special Issue 1/2007

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Abstract

The gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are composed of cells with a neuroendocrine phenotype. Well-differentiated tumors, well-differentiated carcinomas, poorly differentiated carcinomas, functioning tumors (with a hormonal syndrome), and nonfunctioning tumors are identified. To predict their clinical behavior, these neuroendocrine tumors are classified on the basis of their clinicopathological features, including size, local invasion, angioinvasion, proliferative activity, histological differentiation, and metastases, into neoplasms with benign, uncertain, low-grade malignant and high-grade malignant behavior. In addition, a tumor/nodes/metastases classification and a grading system are presented. In the light of these criteria, the various GEP-NET entities are reviewed.
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Metadata
Title
Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors
Authors
Günter Klöppel
Guido Rindi
Martin Anlauf
Aurel Perren
Paul Komminoth
Publication date
01-08-2007
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue Special Issue 1/2007
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-007-0461-0

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