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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2011

Open Access 01-12-2011 | Research

Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome

Authors: Anna Likhacheva, David I Rosenthal, Ehab Hanna, Michael Kupferman, Franco DeMonte, Adel K El-Naggar

Published in: Head & Neck Oncology | Issue 1/2011

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Abstract

Background

The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown.

Methods

We performed a retrospective review of the patients treated for neuroendocrine carcinoma (NEC) of the nasal cavity or paranasal sinuses from 1992 to 2008 at MDACC.

Results

The results of our study suggest that pathologic differentiation may not be a critical factor in the clinical management of patients with NEC of the sinonasal tract. This is in contrast to laryngeal and lung NEC for which pathological differentiation has traditionally guided clinical management.

Conclusion

Mutlimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation. Specifically, RT may provide durable local control for patients with moderately differentiated NEC if resection is not feasible or desirable, while surgical resection can benefit patients with chemo-resistant or radio-resistant disease.
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Metadata
Title
Sinonasal neuroendocrine carcinoma: impact of differentiation status on response and outcome
Authors
Anna Likhacheva
David I Rosenthal
Ehab Hanna
Michael Kupferman
Franco DeMonte
Adel K El-Naggar
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2011
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-3-32

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