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Published in: Diagnostic Pathology 1/2018

Open Access 01-12-2018 | Case Report

Simultaneous occurrence of splenic diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report

Authors: Jing Chang, Qing Chen, Yuan Jian, Ping Wei, Guang-Zhong Yang, Ying Wang, Xiang-Yang Fang, Qian-Mei Sun

Published in: Diagnostic Pathology | Issue 1/2018

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Abstract

Background

Although the primary malignant spleen tumor is relatively rare, lymphoma is the most common splenic malignancy. It can have quite different clinical manifestations that usually lead to relatively poor outcomes, and thus early and accurate diagnosis are of utmost importance.

Case presentation

The present study reports a case of a 67-year-old female with high fever, abnormal spleen (diagnosed by PET/CT) and no obvious lymph node enlargement. After being subjected to splenectomy, the patient was diagnosed with splenic diffuse large B cell lymphoma coexisting with gastrointestinal stromal tumor in the stomach.

Conclusions

To our knowledge, splenic lymphoma accompanied by gastrointestinal stromal tumor in the stomach is rarely reported. This case report discusses the diagnosis and case management of a patient referring to the existing literature.
Literature
1.
go back to reference Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127:2375–90.CrossRefPubMedPubMedCentral Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127:2375–90.CrossRefPubMedPubMedCentral
2.
go back to reference Iorio N, Sawaya RA, Friedenberg FK. Review article: the biology, diagnosis and management of gastrointestinal stromal tumours. Aliment Pharmacol Ther. 2014;39:1376–86.CrossRefPubMed Iorio N, Sawaya RA, Friedenberg FK. Review article: the biology, diagnosis and management of gastrointestinal stromal tumours. Aliment Pharmacol Ther. 2014;39:1376–86.CrossRefPubMed
3.
go back to reference Gao NA, Guo NJ, Yu WZ, Wang XX, Sun JR, Yu N, et al. Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: a case report and review of the literature. Oncol Lett. 2016;11:2977–80.CrossRefPubMedPubMedCentral Gao NA, Guo NJ, Yu WZ, Wang XX, Sun JR, Yu N, et al. Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: a case report and review of the literature. Oncol Lett. 2016;11:2977–80.CrossRefPubMedPubMedCentral
4.
go back to reference Kehoe J, Straus DJ. Primary lymphoma of the spleen. Clinical features and outcome after splenectomy. Cancer. 1988;62:1433–8.CrossRefPubMed Kehoe J, Straus DJ. Primary lymphoma of the spleen. Clinical features and outcome after splenectomy. Cancer. 1988;62:1433–8.CrossRefPubMed
5.
go back to reference Ma J, Jiang Z, Ding T, Xu H, Song J, Zhang J, et al. Splenectomy as a diagnostic method in lymphoma-associated hemophagocytic lymphohistiocytosis of unknown origin. Blood Cancer J. 2017;7:e534.CrossRefPubMedPubMedCentral Ma J, Jiang Z, Ding T, Xu H, Song J, Zhang J, et al. Splenectomy as a diagnostic method in lymphoma-associated hemophagocytic lymphohistiocytosis of unknown origin. Blood Cancer J. 2017;7:e534.CrossRefPubMedPubMedCentral
6.
7.
go back to reference Li M, Zhang L, Wu N, Huang W, Lv N. Imaging findings of primary splenic lymphoma: a review of 17 cases in which diagnosis was made at splenectomy. PLoS One. 2013;8:e80264.CrossRefPubMedPubMedCentral Li M, Zhang L, Wu N, Huang W, Lv N. Imaging findings of primary splenic lymphoma: a review of 17 cases in which diagnosis was made at splenectomy. PLoS One. 2013;8:e80264.CrossRefPubMedPubMedCentral
8.
go back to reference Mollejo M, Algara P, Mateo MS, Menarguez J, Pascual E, Fresno MF, et al. Large B-cell lymphoma presenting in the spleen: identification of different clinicopathologic conditions. Am J Surg Pathol. 2003;27:895–902.CrossRefPubMed Mollejo M, Algara P, Mateo MS, Menarguez J, Pascual E, Fresno MF, et al. Large B-cell lymphoma presenting in the spleen: identification of different clinicopathologic conditions. Am J Surg Pathol. 2003;27:895–902.CrossRefPubMed
9.
go back to reference Han SM, Teng CL, Hwang GY, Chou G, Tsai CA. Primary splenic lymphoma associated with hemophagocytic lymphohistiocytosis complicated with splenic rupture. J Chin Med Assoc. 2008;71:210–3.CrossRefPubMed Han SM, Teng CL, Hwang GY, Chou G, Tsai CA. Primary splenic lymphoma associated with hemophagocytic lymphohistiocytosis complicated with splenic rupture. J Chin Med Assoc. 2008;71:210–3.CrossRefPubMed
10.
go back to reference Takahashi T, Maruyama Y, Saitoh M, Itoh H, Yoshimoto M, Tsujisaki M, et al. Synchronous occurrence of diffuse large B-cell lymphoma of the duodenum and gastrointestinal stromal tumor of the ileum in a patient with immune thrombocytopenic purpura. Intern Med. 2016;55:2951–6.CrossRefPubMedPubMedCentral Takahashi T, Maruyama Y, Saitoh M, Itoh H, Yoshimoto M, Tsujisaki M, et al. Synchronous occurrence of diffuse large B-cell lymphoma of the duodenum and gastrointestinal stromal tumor of the ileum in a patient with immune thrombocytopenic purpura. Intern Med. 2016;55:2951–6.CrossRefPubMedPubMedCentral
11.
go back to reference Murphy JD, Ma GL, Baumgartner JM, Madlensky L, Burgoyne AM, Tang CM, et al. Increased risk of additional cancers among patients with gastrointestinal stromal tumors: a population-based study. Cancer. 2015;121:2960–7.CrossRefPubMedPubMedCentral Murphy JD, Ma GL, Baumgartner JM, Madlensky L, Burgoyne AM, Tang CM, et al. Increased risk of additional cancers among patients with gastrointestinal stromal tumors: a population-based study. Cancer. 2015;121:2960–7.CrossRefPubMedPubMedCentral
Metadata
Title
Simultaneous occurrence of splenic diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report
Authors
Jing Chang
Qing Chen
Yuan Jian
Ping Wei
Guang-Zhong Yang
Ying Wang
Xiang-Yang Fang
Qian-Mei Sun
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2018
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-018-0741-9

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