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Forensic Toxicology
Published in: Forensic Toxicology 2/2012

01-07-2012 | Short Communication

Simultaneous determination of coinage metals, copper, silver, and gold in tissues using electrospray ionization tandem mass spectrometry

Authors: Kayoko Minakata, Itaru Yamagishi, Hideki Nozawa, Kunio Gonmori, Koutaro Hasegawa, Masako Suzuki, Fumihiko Horio, Kanako Watanabe, Osamu Suzuki

Published in: Forensic Toxicology | Issue 2/2012

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Abstract

A rapid and sensitive mass spectrometric method was developed for the simultaneous determination of the coinage metals of copper (Cu), silver (Ag), and gold (Au). The metals in a wet-ashed tissue solution were complexed with diethyldithiocarbamate (DDC; C4H10NCS2) and were extracted with isoamyl alcohol. After acidification of the extract with oxalic acid, metals were quantified using their product ions, Cu(DDCH)+, Ag(DDCH)+, and Au(DDCH)+ that derived from the precursor ions Cu(DDC) 2  + , Ag(DDC) 2  + , and Au(DDC) 2  + , respectively, by electrospray ionization tandem mass spectrometry. The limits of detection were 0.6, 0.3, and 1 μg/l for Cu, Ag, and Au, and the quantification ranges were 2–100, 1–100, and 3–100 μg/l for Cu, Ag, and Au, respectively. Cu levels in spontaneously hypertensive osteogenic disorder rats at 6 weeks of age and 30 weeks of age were found to be 1.8 times and 5.1 times those of the normotensive osteogenic disorder rats, respectively, when using wet-ashed kidney solutions diluted 1000-fold.
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Metadata
Title
Simultaneous determination of coinage metals, copper, silver, and gold in tissues using electrospray ionization tandem mass spectrometry
Authors
Kayoko Minakata
Itaru Yamagishi
Hideki Nozawa
Kunio Gonmori
Koutaro Hasegawa
Masako Suzuki
Fumihiko Horio
Kanako Watanabe
Osamu Suzuki
Publication date
01-07-2012
Publisher
Springer Japan
Published in
Forensic Toxicology / Issue 2/2012
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-012-0134-9

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