Published in:
Open Access
01-03-2015 | Commentary
‘Similar To’ Is Not ‘Identical With’, and ‘Identical With’ Is Not ‘The Same As’
Author:
Wolfgang H. Jost
Published in:
Drugs in R&D
|
Issue 1/2015
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Excerpt
Presently, we have a large number of botulinum neurotoxins (BoNTs) at our disposal, but in the western hemisphere these are limited almost exclusively to the botulinum toxin A preparations: Abo- (ABO), inco- (INCO), and onabotulinumtoxinA (ONA). Because these are biological preparations, they are never identical to each other, but they are, at most, similar to each other. Their efficacy has been well demonstrated in numerous studies and is undebated [
1]. Since their introduction, new batches have repeatedly been made available, and the purity of ABO and ONA has essentially been improved upon. INCO is the most recent formulation and is free of complex proteins. …