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Infectious Agents and Cancer
Published in: Infectious Agents and Cancer 1/2007

Open Access 01-12-2007 | Review

Simian virus 40 in humans

Authors: Fernanda Martini, Alfredo Corallini, Veronica Balatti, Silvia Sabbioni, Cecilia Pancaldi, Mauro Tognon

Published in: Infectious Agents and Cancer | Issue 1/2007

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Abstract

Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells.
Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SV40-contaminated vaccines.
SV40 footprints in humans have been found associated at high prevalence with specific tumor types such as brain and bone tumors, mesotheliomas and lymphomas and with kidney diseases, and at lower prevalence in blood samples from healthy donors.
Contrasting reports appeared in the literature on the circulation of SV40 in humans by contagious transmission and its association, as a possible etiologic cofactor, with specific human tumors. As a consequence of the conflicting results, a considerable debate has developed in the scientific community. In the present review we consider the main results obtained by different groups investigating SV40 sequences in human tumors and in blood specimens, the putative role of SV40 in the onset/progression of specific human tumors, and comment on the hypotheses arising from these data.
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Metadata
Title
Simian virus 40 in humans
Authors
Fernanda Martini
Alfredo Corallini
Veronica Balatti
Silvia Sabbioni
Cecilia Pancaldi
Mauro Tognon
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Infectious Agents and Cancer / Issue 1/2007
Electronic ISSN: 1750-9378
DOI
https://doi.org/10.1186/1750-9378-2-13

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