Silybin and metabolic disorders

Excerpt

Mediterranean diet represents a fundamental strategy in the prevention of cardiovascular and metabolic disorders as demonstrated by observational and interventional trials [1]. Among the most represented elements of the Mediterranean diet are polyphenols that display protective effects on cardiometabolic disorders by counteracting oxidative stress that represent a key point of the preventive strategy in this setting. Hence, oxidative stress seems to be involved in both cardiovascular and metabolic disorders [2]. Indeed, atherosclerotic disease is associated with increased level of oxidative stress [3] as well as metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) [4] and diabetes [5] (Fig. 1).

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