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Annals of Hematology
Published in: Annals of Hematology 4/2003

01-04-2003 | Letter to the Editor

Significance of the ratio of reticulocyte subpopulations in bone marrow and peripheral blood from patients with myelodysplastic syndromes

Authors: J. W. Choi, S. H. Pai, H.-W. Choe

Published in: Annals of Hematology | Issue 4/2003

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Excerpt

Flow cytometric analysis enables evaluating maturation of reticulocytes by quantitating the fraction of reticulocytes within low-, middle-, and high-fluorescence intensity regions (LFR, MFR, and HFR, respectively) [1]. The immature reticulocyte fraction (IRF), the sum of MFR and HFR, which corresponds to young reticulocytes released prematurely, is a useful parameter to evaluate the erythropoietic activity in anemia. The reticulocyte maturity index (RMI) is calculated from the proportion of reticulocyte subpopulations and can be used as the earliest and most sensitive predictor of erythropoiesis [2]. …
Literature
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Chang CC, Kass L (1997) Clinical significance of immature reticulocyte fraction determined by automated reticulocyte counting. Am J Clin Pathol 108:69–73PubMed
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Davis BH, Ornvold K, Bigelow NC (1995) Flow cytometric reticulocyte maturity index: a useful laboratory parameter of erythropoietic activity in anemia. Cytometry 22:35–39PubMed
3.
Williams DA (1995) Stem cell model of hematopoiesis. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE (eds) Hematology: basic principles and practice. Churchill Livingstone, New York, pp 186–187
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Haase D, Fonatsch C, Freund M, Wormann B, Bodenstein H, Bartels H, Stollmann-Gibbels B, Lengfelder E (1995) Cytogenetic findings in 179 patients with myelodysplastic syndromes. Ann Hematol 70:171–187PubMed
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Ataulfo Gonzalez F, Bermejo A, Sanchez J, Anguita E, Villegas A (1997) Value of analyzing reticulocyte subpopulations in polycythemia. Sangre 42:383–386PubMed
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Watanabe K, Kawai Y, Takeuchi K, Shimizu N, Iri H, Ikeda Y, Houwen B (1994) Reticulocyte maturity as an indicator for estimating qualitative abnormality of erythropoiesis. J Clin Pathol 47:736-739PubMed
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Kageoka T (2001) Reticulocyte as indication of the erythroid hematopoiesis: reticulocyte fractions in peripheral blood and bone marrow. Rinsho Byori 49:485-489PubMed
Metadata
Title
Significance of the ratio of reticulocyte subpopulations in bone marrow and peripheral blood from patients with myelodysplastic syndromes
Authors
J. W. Choi
S. H. Pai
H.-W. Choe
Publication date
01-04-2003
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 4/2003
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-003-0634-0

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