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BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Research article

Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

Authors: Sandra Fernandes Martins, Ricardo Amorim, Marta Viana-Pereira, Céline Pinheiro, Ricardo Filipe Alves Costa, Patrícia Silva, Carla Couto, Sara Alves, Sara Fernandes, Sónia Vilaça, Joaquim Falcão, Herlander Marques, Fernando Pardal, Mesquita Rodrigues, Ana Preto, Rui Manuel Reis, Adhemar Longatto-Filho, Fátima Baltazar

Published in: BMC Cancer | Issue 1/2016

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Abstract

Background

Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs). The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cases, lymph node and hepatic metastasis.

Methods

Expressions of MCT1, MCT4, CD147 and GLUT1 were studied in human samples of CRC, lymph node and hepatic metastasis, by immunohistochemistry.

Results

All proteins were overexpressed in primary CRC, lymph node and hepatic metastasis, when compared with non-neoplastic tissue, with exception of MCT1 in lymph node and hepatic metastasis. MCT1 and MCT4 expressions were associated with CD147 and GLUT1 in primary CRC. These markers were associated with clinical pathological features, reflecting the putative role of these metabolism-related proteins in the CRC setting.

Conclusion

These findings provide additional evidence for the pivotal role of MCTs in CRC maintenance and progression, and support the use of MCTs as biomarkers and potential therapeutic targets in primary and metastatic CRC.
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Metadata
Title
Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis
Authors
Sandra Fernandes Martins
Ricardo Amorim
Marta Viana-Pereira
Céline Pinheiro
Ricardo Filipe Alves Costa
Patrícia Silva
Carla Couto
Sara Alves
Sara Fernandes
Sónia Vilaça
Joaquim Falcão
Herlander Marques
Fernando Pardal
Mesquita Rodrigues
Ana Preto
Rui Manuel Reis
Adhemar Longatto-Filho
Fátima Baltazar
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2566-9

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