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MUSCULOSKELETAL SURGERY

Published in:

01-10-2018 | Original Article

Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity

Authors: S. Gumina, V. Candela, A. Castagna, M. Carnovale, D. Passaretti, T. Venditto, G. Giannicola, C. Villani

Published in: MUSCULOSKELETAL SURGERY | Special Issue 1/2018

Abstract

Purpose

Relationship between shoulder adhesive capsulitis (AC) and hypercholesterolemia is known. The connecting link might be represented by the correlation between HDL and transforming growth factor beta (TGF-β): normally, HDLs stimulate TGF-β expression; the latter is employed in the development of fibrous tissue. We assess whether the presence of the Apo-A1-G75A-polymorphism, which is correlated to an enhanced HDL function, could be a risk factor for the genesis and severity of AC.

Methods

Peripheral blood samples of 27 patients [7M; 20F, mean age 54.81 (41–65)] with AC and hypercholesterolemia were submitted to polymerase chain reaction in order to evaluate the Apo-A1-G75A-polymorphism. Genome database was used as control. Two categories were obtained according to AC severity: type I (active forward flexion ≥ 100°) and type II (< 100°). Data were submitted to statistics.

Results

The prevalence of Apo-A1-G75A-polymorphism in the studied group and in the control group was 22.2% (10AG; 1AA; 16GG) and 19% (OR 1.22, IC 0.59–2.53, p > 0.05), respectively. Patients with type I and II capsulitis were 11 [flexion 148.0° (range 100°–165°)] and 16 [flexion 82.5° (range 50°–95°)], respectively. The prevalence of Apo-A1-G75A in type I was 18.1% (2AG; 9GG) and in type II was 56.3% (8GA; 1AA; 7GG), respectively (RR 1.87, IC 1.005–3.482, p < 0.05).

Conclusions

Apo-A1-G75A-polymorphism is not necessary for the genesis, but it is a risk factor for severity of AC.

Level of Evidence

III.

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Title: Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity
Authors: S. Gumina
V. Candela
A. Castagna
M. Carnovale
D. Passaretti
T. Venditto
G. Giannicola
C. Villani
Publication date: 01-10-2018
Publisher: Springer Milan
Published in: MUSCULOSKELETAL SURGERY / Issue Special Issue 1/2018
Print ISSN: 2035-5106
Electronic ISSN: 2035-5114
DOI: https://doi.org/10.1007/s12306-018-0557-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity

Abstract

Purpose

Methods

Results

Conclusions

Level of Evidence

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Level of Evidence

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