Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 5/2013

01-10-2013 | Commentary

Should hydroxyethyl starch solutions be totally banned?

Authors: Jean-Louis Vincent, John A Kellum, Andrew Shaw, Michael G Mythen

Published in: Critical Care | Issue 5/2013

Login to get access

Abstract

The choice of which intravenous solution to prescribe remains a matter ofconsiderable debate in intensive care units around the world. Trends have been movingaway from using hydroxyethyl starch solutions following concerns about safety. Butare the available data sufficient to clearly assess the risk-benefit balance for allpatients, and is there enough evidence of harm to justify removing these drugscompletely from our hospitals?
Appendix
Available only for authorised users
Literature
1.
2.
Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA: Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 2012, 367: 1901-1911. 10.1056/NEJMoa1209759CrossRefPubMed
3.
Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008, 358: 125-139. 10.1056/NEJMoa070716CrossRefPubMed
4.
Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, Madsen KR, Moller MH, Elkjaer JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Soe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjaeldgaard AL, Fabritius ML, Mondrup F, Pott FC, Moller TP, Winkel P, Wetterslev J: Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 2012, 367: 124-134. 10.1056/NEJMoa1204242CrossRefPubMed
5.
Davidson IJ: Renal impact of fluid management with colloids: a comptive review. Eur J Anaesthesiol 2006, 23: 721-738. 10.1017/S0265021506000639CrossRefPubMed
6.
Shaw AD, Bagshaw SM, Goldstein SL, Scherer LA, Duan M, Schermer CR, Kellum JA: Major complications, mortality, and resource utilization after open abdominalsurgery: 0.9% saline compared to Plasma-Lyte. Ann Surg 2012, 255: 821-829. 10.1097/SLA.0b013e31825074f5CrossRefPubMed
7.
Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M: Association between a chloride-liberal vs chloride-restrictive intravenous fluidadministration strategy and kidney injury in critically ill adults. JAMA 2012, 308: 1566-1572. 10.1001/jama.2012.13356CrossRefPubMed
8.
Kellum JA, James MF: Why do intensivists still use hydroxyethyl starch? Crit Care Med 2010, 38: 2260-2262. 10.1097/CCM.0b013e3181f8fa15CrossRefPubMed
9.
Metadata
Title
Should hydroxyethyl starch solutions be totally banned?
Authors
Jean-Louis Vincent
John A Kellum
Andrew Shaw
Michael G Mythen
Publication date
01-10-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13027

Other articles of this Issue 5/2013

Critical Care 5/2013 Go to the issue

Research

Risk factors for intra-abdominal hypertension and abdominal compartment syndrome among adult intensive care unit patients: a systematic review and meta-analysis

Letter

The 372 T/C genetic polymorphism of TIMP-1 as a biomarker of mortality in patients with sepsis

Research

Pattern of Brain Injury in the Acute Setting of Human Septic Shock

Commentary

Predicting treatment failure in severe sepsis and septic shock: looking for the Holy Grail

Research

Glycaemic control in Australia and New Zealand before and after the NICE-SUGAR trial: a translational study

Research

Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome