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01-04-2005 | Original Article

Short-term functional and neuroregenerative response of the urethra to ovariectomy and vaginal distension in female rats

Authors: Corri L. Ferguson, Dan Li Lin, Soujanya Rao, Margot S. Damaser

Published in: International Urogynecology Journal | Issue 2/2005

Abstract

The objective of this study was to investigate the effects of ovariectomy (OVX) and vaginal distension (VD) on leak point pressure (LPP) and pudendal nerve regenerative response in the female rat. Twenty rats underwent OVX 3 days prior to either VD or sham distension. Seventeen rats did not receive OVX but underwent either VD or sham distension. Four days after distension, LPP testing was performed. In situ hybridization for β_II tubulin mRNA, an indicator of the neuroregenerative response, was performed on motoneurons of the pudendal nerve. In the non-OVX group, LPP was significantly decreased after VD. After OVX, the difference in LPP between VD and sham rats did not quite reach the level of statistical significance. There was a statistically significant interaction between the effects of OVX and VD on LPP. There was no significant difference in in situ hybridization results between any of the groups. No neuroregenerative response of motoneurons of the pudendal nerve was observed after either VD or OVX.

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Title: Short-term functional and neuroregenerative response of the urethra to ovariectomy and vaginal distension in female rats
Authors: Corri L. Ferguson
Dan Li Lin
Soujanya Rao
Margot S. Damaser
Publication date: 01-04-2005
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 2/2005
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-004-1237-6

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Short-term functional and neuroregenerative response of the urethra to ovariectomy and vaginal distension in female rats

Abstract

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Abstract

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