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Open Access 01-09-2017 | Gastrointestinal Oncology

Short-Course Radiotherapy Followed by Neoadjuvant Bevacizumab, Capecitabine, and Oxaliplatin and Subsequent Radical Treatment in Primary Stage IV Rectal Cancer: Long-Term Results of a Phase II Study

Authors: C. Bisschop, MD, T. H. van Dijk, MD, J. C. Beukema, MD, R. L. H. Jansen, MD, PhD, H. Gelderblom, MD, PhD, K. P. de Jong, MD, PhD, H. J. T. Rutten, MD, PhD, C. J. H. van de Velde, MD, PhD, T. Wiggers, MD, PhD, K. Havenga, MD, PhD, G. A. P. Hospers, MD, PhD

Published in: Annals of Surgical Oncology | Issue 9/2017

Abstract

Background

In a Dutch phase II trial conducted between 2006 and 2010, short-course radiotherapy followed by systemic therapy with capecitabine, oxaliplatin, and bevacizumab as neoadjuvant treatment and subsequent radical surgical treatment of primary tumor and metastatic sites was evaluated. In this study, we report the long-term results after a minimum follow-up of 6 years.

Methods

Patients with histologically confirmed rectal adenocarcinoma with potentially resectable or ablatable metastases in liver or lungs were eligible. Follow-up data were collected for all patients enrolled in the trial. Overall and recurrence-free survival were calculated using the Kaplan–Meier method.

Results

Follow-up data were available for all 50 patients. After a median follow-up time of 8.1 years (range 6.0–9.8), 16 patients (32.0%) were still alive and 14 (28%) were disease-free. The median overall survival was 3.8 years (range 0.5–9.4). From the 36 patients who received radical treatment, two (5.6%) had a local recurrence and 29 (80.6%) had a distant recurrence.

Conclusions

Long-term survival can be achieved in patients with primary metastatic rectal cancer after neoadjuvant radio- and chemotherapy. Despite a high number of recurrences, 32% of patients were alive after a median follow-up time of 8.1 years.

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Title: Short-Course Radiotherapy Followed by Neoadjuvant Bevacizumab, Capecitabine, and Oxaliplatin and Subsequent Radical Treatment in Primary Stage IV Rectal Cancer: Long-Term Results of a Phase II Study
Authors: C. Bisschop, MD
T. H. van Dijk, MD
J. C. Beukema, MD
R. L. H. Jansen, MD, PhD
H. Gelderblom, MD, PhD
K. P. de Jong, MD, PhD
H. J. T. Rutten, MD, PhD
C. J. H. van de Velde, MD, PhD
T. Wiggers, MD, PhD
K. Havenga, MD, PhD
G. A. P. Hospers, MD, PhD
Publication date: 01-09-2017
Publisher: Springer International Publishing
Published in: Annals of Surgical Oncology / Issue 9/2017
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-017-5897-0

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Short-Course Radiotherapy Followed by Neoadjuvant Bevacizumab, Capecitabine, and Oxaliplatin and Subsequent Radical Treatment in Primary Stage IV Rectal Cancer: Long-Term Results of a Phase II Study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

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Abstract

Background

Methods

Results

Conclusions

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