Skip to main content
Top
Published in: Diabetology & Metabolic Syndrome 1/2020

01-12-2020 | Research

Short and long term effect of treatment non-pharmacological and lifestyle in patients with metabolic syndrome

Authors: Ana Denise Brandão, Jeferson Hernandes da Silva, Sarah Mariane Oliveira Lima, Leiciane Lima, Bhianca Loize, Antônio Adolfo Mattos de Castro, Claudia Kümpel, Elias Ferreira Porto

Published in: Diabetology & Metabolic Syndrome | Issue 1/2020

Login to get access

Abstract

Background

Metabolic syndrome (MS) is a complex disorder represented by a set of cardiovascular risk factors usually related to central fat deposition, insulin resistance, hypertension and dyslipidemia. It is associated with accelerated atherosclerosis in response to chronic inflammation and vascular endothelial dysfunction, increasing overall mortality. The objective to evaluate the short and long term effect of the comprehensive cardiac rehabilitation program and intensive lifestyle intervention in metabolic syndrome patients.

Methods

This is longitudinal interventional study. All patients underwent a 20-session cardiac rehabilitation program with aerobic and resisted exercises as well as an educational program for lifestyle changes and follow up 1 year.

Results

Forty seven patients participated in the present study, but only 28 concluded the follow up. 77.7% were females and the majority was older than 60 years (63.1%). After cardiac rehabilitation, the percentage of overweight (0.04) patients who controlled the SBP (0.04) increased, and obesity levels I and II were reduced, as well as a significant reduction in total cholesterol and triglycerides (0.01 and 0.05), all of these variables remained similar after 1 year of follow-up. After cardiac rehabilitation all participants were practicing the five factors of healthy lifestyle, and reduced to 73% after follow up.

Conclusion

A comprehensive cardiac rehabilitation program and lifestyle change is an effective approach in the treatment of patients with MS mainly, it has positive short and long term effects on weight control, reducing total cholesterol and triglycerides.
Literature
1.
go back to reference Kuschnir MCC, Bloch KV, Szklo M, Klein CH, Barufaldi LA, Abreu GDA, Moraes AJPD. ERICA: prevalence of metabolic syndrome in Brazilian adolescents. Revista de saúde Pública. 2016;50(11):256–68. Kuschnir MCC, Bloch KV, Szklo M, Klein CH, Barufaldi LA, Abreu GDA, Moraes AJPD. ERICA: prevalence of metabolic syndrome in Brazilian adolescents. Revista de saúde Pública. 2016;50(11):256–68.
2.
go back to reference Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third national health and nutrition examination survey. JAMA. 2002;287(3):356–9.CrossRef Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third national health and nutrition examination survey. JAMA. 2002;287(3):356–9.CrossRef
3.
go back to reference Azizi F, Salehi P, Etemadi A, Zahedi-Asl S. Prevalence of metabolic syndrome in an urban population: tehran lipid and glucose study. Diabet Res Clin Pract. 2003;61(1):29–37.CrossRef Azizi F, Salehi P, Etemadi A, Zahedi-Asl S. Prevalence of metabolic syndrome in an urban population: tehran lipid and glucose study. Diabet Res Clin Pract. 2003;61(1):29–37.CrossRef
4.
go back to reference Porto EF, Souza AC. Health promotion and lifestyle: limitations and perspectives. Lifestyle J. 2016;4(2):7–9. Porto EF, Souza AC. Health promotion and lifestyle: limitations and perspectives. Lifestyle J. 2016;4(2):7–9.
5.
go back to reference Takahara M, Shimomura I. Metabolic syndrome and lifestyle modification. Rev Endocr Metab Disord. 2014;15(4):317–27.PubMedCrossRef Takahara M, Shimomura I. Metabolic syndrome and lifestyle modification. Rev Endocr Metab Disord. 2014;15(4):317–27.PubMedCrossRef
6.
go back to reference Orchard TJ, Temprosa M, Goldberg R, Haffner S, Ratner R, Marcovina S, Fowler S. The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the diabetes prevention program randomized trial. Ann Intern Med. 2005;142(8):611–9.PubMedPubMedCentralCrossRef Orchard TJ, Temprosa M, Goldberg R, Haffner S, Ratner R, Marcovina S, Fowler S. The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the diabetes prevention program randomized trial. Ann Intern Med. 2005;142(8):611–9.PubMedPubMedCentralCrossRef
7.
go back to reference Lavie CJ, Milani RV. Cardiac rehabilitation and exercise training programs in metabolic syndrome and diabetes. J Cardiopul Rehabil Prev. 2005;25(2):59–66.CrossRef Lavie CJ, Milani RV. Cardiac rehabilitation and exercise training programs in metabolic syndrome and diabetes. J Cardiopul Rehabil Prev. 2005;25(2):59–66.CrossRef
8.
go back to reference Jakicic JM, Marcus BH, Gallagher KI, Napolitano M, Lang W. Effect of exercise duration and intensity on weight loss in overweight, sedentary women: a randomized trial. JAMA. 2003;290(10):1323–30.PubMedCrossRef Jakicic JM, Marcus BH, Gallagher KI, Napolitano M, Lang W. Effect of exercise duration and intensity on weight loss in overweight, sedentary women: a randomized trial. JAMA. 2003;290(10):1323–30.PubMedCrossRef
9.
go back to reference Jakicic JM, Marcus BH, Lang W, Janney C. Effect of exercise on 24-month weight loss maintenance in overweight women. Arch Intern Med. 2008;168(14):1550–9.PubMedPubMedCentralCrossRef Jakicic JM, Marcus BH, Lang W, Janney C. Effect of exercise on 24-month weight loss maintenance in overweight women. Arch Intern Med. 2008;168(14):1550–9.PubMedPubMedCentralCrossRef
10.
go back to reference Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr. 1995;49(1):1–10.PubMedCrossRef Garrow JS, Summerbell CD. Meta-analysis: effect of exercise, with or without dieting, on the body composition of overweight subjects. Eur J Clin Nutr. 1995;49(1):1–10.PubMedCrossRef
11.
go back to reference Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, Fallucca S, Alessi E, Letizia C, Jimenez A, Fallucca F. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis. 2010;20(8):608–17.PubMedCrossRef Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, Fallucca S, Alessi E, Letizia C, Jimenez A, Fallucca F. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis. 2010;20(8):608–17.PubMedCrossRef
12.
go back to reference Martins C, Kulseng B, King NA, Holst JJ, Blundell JE. The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. J Clin Endocrinol Metab. 2010;95(4):1609–16.PubMedCrossRef Martins C, Kulseng B, King NA, Holst JJ, Blundell JE. The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat. J Clin Endocrinol Metab. 2010;95(4):1609–16.PubMedCrossRef
13.
go back to reference Thompson PD, Yurgalevitch SM, Flynn MM, Zmuda JM, Spannaus-Martin D, Saritelli A, Bausserman L, Herbert PN. Effect of prolonged exercise training without weight loss on high-density lipoprotein metabolism in overweight men. Metabolism. 1997;46(2):217–23.PubMedCrossRef Thompson PD, Yurgalevitch SM, Flynn MM, Zmuda JM, Spannaus-Martin D, Saritelli A, Bausserman L, Herbert PN. Effect of prolonged exercise training without weight loss on high-density lipoprotein metabolism in overweight men. Metabolism. 1997;46(2):217–23.PubMedCrossRef
14.
go back to reference Reis VMCP, Passos BMA, Rocha JSB, Freitas RF, Santos GS, Fonseca AA, Pitanga FG. Effect of resistance training aqua aerobics on the lipid profile of postmenopausal women. ConScientiae Saúde. 2014;13(4):571–7.CrossRef Reis VMCP, Passos BMA, Rocha JSB, Freitas RF, Santos GS, Fonseca AA, Pitanga FG. Effect of resistance training aqua aerobics on the lipid profile of postmenopausal women. ConScientiae Saúde. 2014;13(4):571–7.CrossRef
15.
go back to reference de Castro AAM, Kumpel C, Porto EF, Menezes E, Carpes MF, Malheiros RT, Oliveira SC. Comparative analysis of levels of glycemia in individuals practicing physical activity and sedentary. Life Style. 2016;3(1):49–66.CrossRef de Castro AAM, Kumpel C, Porto EF, Menezes E, Carpes MF, Malheiros RT, Oliveira SC. Comparative analysis of levels of glycemia in individuals practicing physical activity and sedentary. Life Style. 2016;3(1):49–66.CrossRef
16.
go back to reference Hurley BF. Effects of resistive training on lipoprotein–lipid profiles: a comparison to aerobic exercise training. Med Sci Sports Exerc. 1989;21:689–93.PubMedCrossRef Hurley BF. Effects of resistive training on lipoprotein–lipid profiles: a comparison to aerobic exercise training. Med Sci Sports Exerc. 1989;21:689–93.PubMedCrossRef
17.
go back to reference Martín S, Elosua R, Covas MI, Pavesi M, Vila J, Marrugat J. Relationship of lipoprotein (a) levels to physical activity and family history of coronary heart disease. Am J Public Health. 1999;89:383–5.PubMedPubMedCentralCrossRef Martín S, Elosua R, Covas MI, Pavesi M, Vila J, Marrugat J. Relationship of lipoprotein (a) levels to physical activity and family history of coronary heart disease. Am J Public Health. 1999;89:383–5.PubMedPubMedCentralCrossRef
18.
go back to reference Prado ES, Dantas EHM. Efeitos dos exercícios físicos aeróbio e de força nas lipoproteínas HDL, LDL e lipoproteína (a). Arq Bras Cardiol. 2002;79(4):429–33.PubMedCrossRef Prado ES, Dantas EHM. Efeitos dos exercícios físicos aeróbio e de força nas lipoproteínas HDL, LDL e lipoproteína (a). Arq Bras Cardiol. 2002;79(4):429–33.PubMedCrossRef
19.
go back to reference Leon AS, Franklin BA, Costa F, Balady GJ, Berra KA, Stewart KJ, Lauer MS. Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Assoc. Scientific statement from the council on Clin. Cardiol. (Subcommittee on Exercise, cardiac Rehabil., and Prevention) and the Council on Nutr., phys. Activity, and Metab. (Subcommittee on Phys. Activity), in collaboration with the Am. Assoc. of Cardiovasc. and Pulmonary Rehabil. Circulation. 2005;111(3):369–76.PubMedCrossRef Leon AS, Franklin BA, Costa F, Balady GJ, Berra KA, Stewart KJ, Lauer MS. Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Assoc. Scientific statement from the council on Clin. Cardiol. (Subcommittee on Exercise, cardiac Rehabil., and Prevention) and the Council on Nutr., phys. Activity, and Metab. (Subcommittee on Phys. Activity), in collaboration with the Am. Assoc. of Cardiovasc. and Pulmonary Rehabil. Circulation. 2005;111(3):369–76.PubMedCrossRef
20.
go back to reference Ciolac EG, Guimarães GV. Ejercicio físico y síndrome metabólico. Rev Bras Med Esporte. 2004;10(4):319–24.CrossRef Ciolac EG, Guimarães GV. Ejercicio físico y síndrome metabólico. Rev Bras Med Esporte. 2004;10(4):319–24.CrossRef
21.
go back to reference Ferguson CJ. An effect size booklet: a guide for doctors and researchers. In: AE Kazdin, editor. Methodological issues and strategies in clinical research. American Psychological Association, 2016. p. 301–310. https://doi.org/10.1037/14805-020. Ferguson CJ. An effect size booklet: a guide for doctors and researchers. In: AE Kazdin, editor. Methodological issues and strategies in clinical research. American Psychological Association, 2016. p. 301–310. https://​doi.​org/​10.​1037/​14805-020.
22.
go back to reference Colombo CM, Macedo RMD, Fernandes-Silva MM, Caporal AM, Stinghen AE, Constantini CR, Baena CP, Guarita-Souza LC, Faria-Neto JR. Short-term effects of moderate intensity physical activity in patients with metabolic syndrome. Einstein (São Paulo). 2013;11(3):324–30.CrossRef Colombo CM, Macedo RMD, Fernandes-Silva MM, Caporal AM, Stinghen AE, Constantini CR, Baena CP, Guarita-Souza LC, Faria-Neto JR. Short-term effects of moderate intensity physical activity in patients with metabolic syndrome. Einstein (São Paulo). 2013;11(3):324–30.CrossRef
23.
go back to reference Moreira MM, Souza H, Schwingel PA, Sá CKCD, Zoppi CC. Efeitos do exercício aeróbico e anaeróbico em variáveis de risco cardíaco em adultos com sobrepeso. Arq Bras Cardiol. 2008;91(4):200–6.PubMedCrossRef Moreira MM, Souza H, Schwingel PA, Sá CKCD, Zoppi CC. Efeitos do exercício aeróbico e anaeróbico em variáveis de risco cardíaco em adultos com sobrepeso. Arq Bras Cardiol. 2008;91(4):200–6.PubMedCrossRef
Metadata
Title
Short and long term effect of treatment non-pharmacological and lifestyle in patients with metabolic syndrome
Authors
Ana Denise Brandão
Jeferson Hernandes da Silva
Sarah Mariane Oliveira Lima
Leiciane Lima
Bhianca Loize
Antônio Adolfo Mattos de Castro
Claudia Kümpel
Elias Ferreira Porto
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2020
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/s13098-020-0522-y

Other articles of this Issue 1/2020

Diabetology & Metabolic Syndrome 1/2020 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine