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Intensive Care Medicine
Published in: Intensive Care Medicine 12/2020

01-12-2020 | Shock | Narrative Review

Transfusion in the mechanically ventilated patient

Authors: Nicole P. Juffermans, Cécile Aubron, Jacques Duranteau, Alexander P. J. Vlaar, Daryl J. Kor, Jennifer A. Muszynski, Philip C. Spinella, Jean-Louis Vincent

Published in: Intensive Care Medicine | Issue 12/2020

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Abstract

Red blood cell transfusions are a frequent intervention in critically ill patients, including in those who are receiving mechanical ventilation. Both these interventions can impact negatively on lung function with risks of transfusion-related acute lung injury (TRALI) and other forms of acute respiratory distress syndrome (ARDS). The interactions between transfusion, mechanical ventilation, TRALI and ARDS are complex and other patient-related (e.g., presence of sepsis or shock, disease severity, and hypervolemia) or blood product-related (e.g., presence of antibodies or biologically active mediators) factors also play a role. We propose several strategies targeted at these factors that may help limit the risks of associated lung injury in critically ill patients being considered for transfusion.
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Metadata
Title
Transfusion in the mechanically ventilated patient
Authors
Nicole P. Juffermans
Cécile Aubron
Jacques Duranteau
Alexander P. J. Vlaar
Daryl J. Kor
Jennifer A. Muszynski
Philip C. Spinella
Jean-Louis Vincent
Publication date
01-12-2020
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 12/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-020-06303-z

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