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07-03-2024 | Shingles | Short Communication

Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aβ40/42 alterations in serum and cerebrospinal fluid

Authors: Christy S. Niemeyer, Vicki Traina-Dorge, Lara Doyle-Meyers, Arpita Das, Jayme Looper, Teresa Mescher, Brittany Feia, Eva Medina, Maria A. Nagel, Ravi Mahalingam, Andrew N. Bubak

Published in: Journal of NeuroVirology | Issue 1/2024

Abstract

Simian varicella virus (SVV) produces peripheral inflammatory responses during varicella (primary infection) and zoster (reactivation) in rhesus macaques (RM). However, it is unclear if peripheral measures are accurate proxies for central nervous system (CNS) responses. Thus, we analyzed cytokine and Aβ42/Aβ40 changes in paired serum and cerebrospinal fluid (CSF) during the course of infection. During varicella and zoster, every RM had variable changes in serum and CSF cytokine and Aβ42/Aβ40 levels compared to pre-inoculation levels. Overall, peripheral infection appears to affect CNS cytokine and Aβ42/Aβ40 levels independent of serum responses, suggesting that peripheral disease may contribute to CNS disease.

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Title: Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aβ40/42 alterations in serum and cerebrospinal fluid
Authors: Christy S. Niemeyer
Vicki Traina-Dorge
Lara Doyle-Meyers
Arpita Das
Jayme Looper
Teresa Mescher
Brittany Feia
Eva Medina
Maria A. Nagel
Ravi Mahalingam
Andrew N. Bubak
Publication date: 07-03-2024
Publisher: Springer International Publishing
Keywords: Shingles
Cytokines
Human Alphaherpesvirus 3
Published in: Journal of NeuroVirology / Issue 1/2024
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-024-01196-w

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Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aβ40/42 alterations in serum and cerebrospinal fluid

Abstract

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Abstract

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