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BMC Urology
Published in: BMC Urology 1/2012

Open Access 01-12-2012 | Case report

Severe paraneoplastic hypereosinophilia in metastatic renal cell carcinoma

Authors: Tilman Todenhöfer, Stefan Wirths, Claus Hann von Weyhern, Stefan Heckl, Marius Horger, Joerg Hennenlotter, Arnulf Stenzl, Lothar Kanz, Christian Schwentner

Published in: BMC Urology | Issue 1/2012

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Abstract

Background

Renal cell carcinoma can cause various paraneoplastic syndromes including metabolic and hematologic disturbances. Paraneoplastic hypereosinophilia has been reported in a variety of hematologic and solid tumors. We present the first case in the literature of severe paraneoplastic hypereosinophilia in a patient with renal cell carcinoma.

Case presentation

A 46 year-old patient patient with a history of significant weight loss, reduced general state of health and coughing underwent radical nephrectomy for metastasized renal cell carcinoma. Three weeks after surgery, the patient presented with excessive peripheral hypereosinophilia leading to profound neurological symptoms due to cerebral microinfarction. Systemic treatment with prednisolone, hydroxyurea, vincristine, cytarabine, temsirolimus and sunitinib led to reduction of peripheral eosinophils but could not prevent rapid disease progression of the patient. At time of severe leukocytosis, a considerable increase of cytokines associated with hypereosinophilia was measurable.

Conclusions

Paraneoplastic hypereosinophilia in patients with renal cell carcinoma might indicate poor prognosis and rapid disease progression. Myelosuppressive therapy is required in symptomatic patients.
Appendix
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Metadata
Title
Severe paraneoplastic hypereosinophilia in metastatic renal cell carcinoma
Authors
Tilman Todenhöfer
Stefan Wirths
Claus Hann von Weyhern
Stefan Heckl
Marius Horger
Joerg Hennenlotter
Arnulf Stenzl
Lothar Kanz
Christian Schwentner
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2012
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/1471-2490-12-7

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