Skip to main content
Top
Published in: BMC Surgery 1/2011

Open Access 01-12-2011 | Case report

Severe gastric variceal haemorrhage due to splenic artery thrombosis and consecutive arterial bypass

Authors: Klaus T von Trotha, Marcel Binnebösel, Son Truong, Florian F Behrendt, Hermann E Wasmuth, Ulf P Neumann, Marc Jansen

Published in: BMC Surgery | Issue 1/2011

Login to get access

Abstract

Background

Upper gastrointestinal haemorrhage is mainly caused by ulcers. Gastric varicosis due to portal hypertension can also be held responsible for upper gastrointestinal bleeding. Portal hypertension causes the development of a collateral circulation from the portal to the caval venous system resulting in development of oesophageal and gastric fundus varices. Those may also be held responsible for upper gastrointestinal haemorrhage.

Case presentation

In this study, we describe the case of a 69-year-old male with recurrent severe upper gastrointestinal bleeding caused by arterial submucosal collaterals due to idiopathic splenic artery thrombosis. The diagnosis was secured using endoscopic duplex ultrasound and angiography. The patient was successfully treated with a laparoscopic splenectomy and complete dissection of the short gastric arteries, resulting in the collapse of the submucosal arteries in the gastric wall. Follow-up gastroscopy was performed on the 12th postoperative week and showed no signs of bleeding and a significant reduction in the arterial blood flow within the gastric wall. Subsequent follow-up after 6 months also showed no further gastrointestinal bleeding as well as subjective good quality of life for the patient.

Conclusion

Submucosal arterial collaterals must be excluded by endosonography via endoscopy in case of recurrent upper gastrointestinal bleeding. Laparoscopic splenectomy provides adequate treatment in preventing any recurrent bleeding, if gastric arterial collaterals are caused by splenic artery thrombosis.
Appendix
Available only for authorised users
Literature
1.
go back to reference van Leerdam ME: Epidemiology of acute upper gastrointestinal bleeding. Best Pract Res Clin Gastroenterol. 2008, 22: 209-224. 10.1016/j.bpg.2007.10.011.CrossRefPubMed van Leerdam ME: Epidemiology of acute upper gastrointestinal bleeding. Best Pract Res Clin Gastroenterol. 2008, 22: 209-224. 10.1016/j.bpg.2007.10.011.CrossRefPubMed
2.
go back to reference Dror S, Dani BZ, Ur M, Yoram K: Spontaneous thrombosis of a splenic pseudoaneurysm after blunt abdominal trauma. J Trauma. 2002, 53: 383-385. 10.1097/00005373-200208000-00035.CrossRefPubMed Dror S, Dani BZ, Ur M, Yoram K: Spontaneous thrombosis of a splenic pseudoaneurysm after blunt abdominal trauma. J Trauma. 2002, 53: 383-385. 10.1097/00005373-200208000-00035.CrossRefPubMed
3.
go back to reference Gow KW, Murphy JJ, Blair GK, Stringer DA, Culham JA, Fraser GC: Splanchnic artery pseudo-aneurysms secondary to blunt abdominal trauma in children. J Pediatr Surg. 1996, 31: 812-815. 10.1016/S0022-3468(96)90140-2.CrossRefPubMed Gow KW, Murphy JJ, Blair GK, Stringer DA, Culham JA, Fraser GC: Splanchnic artery pseudo-aneurysms secondary to blunt abdominal trauma in children. J Pediatr Surg. 1996, 31: 812-815. 10.1016/S0022-3468(96)90140-2.CrossRefPubMed
4.
go back to reference Kalra BS, Chaturvedi S, Tayal V, Gupta U: Evaluation of gastric tolerability, antinociceptive and antiinflammatory activity of combination NSAIDs in rats. Indian J Dent Res. 2009, 20: 418-422. 10.4103/0970-9290.59439.CrossRefPubMed Kalra BS, Chaturvedi S, Tayal V, Gupta U: Evaluation of gastric tolerability, antinociceptive and antiinflammatory activity of combination NSAIDs in rats. Indian J Dent Res. 2009, 20: 418-422. 10.4103/0970-9290.59439.CrossRefPubMed
5.
go back to reference Redeen S, Petersson F, Kechagias S, Mardh E, Borch K: Natural history of chronic gastritis in a population-based cohort. Scand J Gastroenterol. 2010, 45 ((5)): 540-9.CrossRefPubMed Redeen S, Petersson F, Kechagias S, Mardh E, Borch K: Natural history of chronic gastritis in a population-based cohort. Scand J Gastroenterol. 2010, 45 ((5)): 540-9.CrossRefPubMed
6.
go back to reference Garcia-Tsao G, Lim JK: Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program. Am J Gastroenterol. 2009, 104: 1802-1829. 10.1038/ajg.2009.191.CrossRefPubMed Garcia-Tsao G, Lim JK: Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program. Am J Gastroenterol. 2009, 104: 1802-1829. 10.1038/ajg.2009.191.CrossRefPubMed
8.
go back to reference Navarro VJ, Garcia-Tsao G: Variceal hemorrhage. Crit Care Clin. 1995, 11: 391-414.PubMed Navarro VJ, Garcia-Tsao G: Variceal hemorrhage. Crit Care Clin. 1995, 11: 391-414.PubMed
9.
go back to reference Baron PW, Sindram D, Suhocki P, Webb DD, Clavien PA: Upper gastrointestinal bleeding from gastric submucosal arterial collaterals secondary to splenic artery occlusion: treatment by splenectomy and partial gastric devascularization. Am J Gastroenterol. 2000, 95: 3003-3004. 10.1111/j.1572-0241.2000.03228.x.CrossRefPubMed Baron PW, Sindram D, Suhocki P, Webb DD, Clavien PA: Upper gastrointestinal bleeding from gastric submucosal arterial collaterals secondary to splenic artery occlusion: treatment by splenectomy and partial gastric devascularization. Am J Gastroenterol. 2000, 95: 3003-3004. 10.1111/j.1572-0241.2000.03228.x.CrossRefPubMed
10.
go back to reference Cyrany J, Kopacova M, Rejchrt S, Jirkovsky V, Al-Tashi M, Bures J: Gastric arterial bleeding secondary to chronic occlusion of the splenic artery (with video). Gastrointest Endosc. 2010, 71: 1335-10.1016/j.gie.2009.09.039.CrossRefPubMed Cyrany J, Kopacova M, Rejchrt S, Jirkovsky V, Al-Tashi M, Bures J: Gastric arterial bleeding secondary to chronic occlusion of the splenic artery (with video). Gastrointest Endosc. 2010, 71: 1335-10.1016/j.gie.2009.09.039.CrossRefPubMed
11.
go back to reference Mnatzakanian G, Smaggus A, Wang CS, Common AA, Jeejeebhoy KN: Splenic artery collaterals masquerading as gastric fundal varices on endoscopy: a sticky situation. Gastrointest Endosc. 2008, 67: 751-755. 10.1016/j.gie.2007.09.044.CrossRefPubMed Mnatzakanian G, Smaggus A, Wang CS, Common AA, Jeejeebhoy KN: Splenic artery collaterals masquerading as gastric fundal varices on endoscopy: a sticky situation. Gastrointest Endosc. 2008, 67: 751-755. 10.1016/j.gie.2007.09.044.CrossRefPubMed
12.
go back to reference Durrans D, Fawcitt RA, Taylor TV: Congenital absence of the splenic artery associated with major gastric bleeding in adolescence. Br J Surg. 1985, 72: 456-457. 10.1002/bjs.1800720618.CrossRefPubMed Durrans D, Fawcitt RA, Taylor TV: Congenital absence of the splenic artery associated with major gastric bleeding in adolescence. Br J Surg. 1985, 72: 456-457. 10.1002/bjs.1800720618.CrossRefPubMed
13.
go back to reference Spriggs DW: Congenital absence of the splenic artery. Cardiovasc Intervent Radiol. 1984, 7: 303-305. 10.1007/BF02625116.CrossRefPubMed Spriggs DW: Congenital absence of the splenic artery. Cardiovasc Intervent Radiol. 1984, 7: 303-305. 10.1007/BF02625116.CrossRefPubMed
14.
go back to reference Mogl MT, Nussler NC, Presser SJ, Podrabsky P, Denecke T, Grieser C, Neuhaus P, Guckelberger O: Evolving experience with prevention and treatment of splenic artery syndrome after orthotopic liver transplantation. Transpl Int. 2010 Mogl MT, Nussler NC, Presser SJ, Podrabsky P, Denecke T, Grieser C, Neuhaus P, Guckelberger O: Evolving experience with prevention and treatment of splenic artery syndrome after orthotopic liver transplantation. Transpl Int. 2010
15.
go back to reference Vogl TJ, Pegios W, Balzer JO, Lobo M, Neuhaus P: [Arterial steal syndrome in patients after liver transplantation: transarterial embolization of the splenic and gastroduodenal arteries]. Rofo. 2001, 173: 908-913.CrossRefPubMed Vogl TJ, Pegios W, Balzer JO, Lobo M, Neuhaus P: [Arterial steal syndrome in patients after liver transplantation: transarterial embolization of the splenic and gastroduodenal arteries]. Rofo. 2001, 173: 908-913.CrossRefPubMed
16.
go back to reference Vincent M, Lerat F, Trogrlic S, Laurent V, Feray C, Dupas B: [Left renal vein thrombosis following sclerotherapy for gastric varices]. J Radiol. 2009, 90: 745-746. 10.1016/S0221-0363(09)74732-8.CrossRefPubMed Vincent M, Lerat F, Trogrlic S, Laurent V, Feray C, Dupas B: [Left renal vein thrombosis following sclerotherapy for gastric varices]. J Radiol. 2009, 90: 745-746. 10.1016/S0221-0363(09)74732-8.CrossRefPubMed
17.
go back to reference Yu LK, Hsu CW, Tseng JH, Liu NJ, Sheen IS: Splenic infarction complicated by splenic artery occlusion after N-butyl-2-cyanoacrylate injection for gastric varices: case report. Gastrointest Endosc. 2005, 61: 343-345. 10.1016/S0016-5107(04)02583-0.CrossRefPubMed Yu LK, Hsu CW, Tseng JH, Liu NJ, Sheen IS: Splenic infarction complicated by splenic artery occlusion after N-butyl-2-cyanoacrylate injection for gastric varices: case report. Gastrointest Endosc. 2005, 61: 343-345. 10.1016/S0016-5107(04)02583-0.CrossRefPubMed
18.
go back to reference Amouroux C, Cervoni JP, Delabrousse E, Koch S, Thevenot T, Di M V: [Portal vein thrombosis after cyanoacrylate injection therapy in bleeding gastric varices]. Gastroenterol Clin Biol. 2009, 33: 205-207. 10.1016/j.gcb.2009.01.006.CrossRefPubMed Amouroux C, Cervoni JP, Delabrousse E, Koch S, Thevenot T, Di M V: [Portal vein thrombosis after cyanoacrylate injection therapy in bleeding gastric varices]. Gastroenterol Clin Biol. 2009, 33: 205-207. 10.1016/j.gcb.2009.01.006.CrossRefPubMed
19.
go back to reference Vormittag R, Simanek R, Ay C, Dunkler D, Quehenberger P, Marosi C, Zielinski C, Pabinger I: High factor VIII levels independently predict venous thromboembolism in cancer patients: the cancer and thrombosis study. Arterioscler Thromb Vasc Biol. 2009, 29: 2176-2181. 10.1161/ATVBAHA.109.190827.CrossRefPubMed Vormittag R, Simanek R, Ay C, Dunkler D, Quehenberger P, Marosi C, Zielinski C, Pabinger I: High factor VIII levels independently predict venous thromboembolism in cancer patients: the cancer and thrombosis study. Arterioscler Thromb Vasc Biol. 2009, 29: 2176-2181. 10.1161/ATVBAHA.109.190827.CrossRefPubMed
20.
go back to reference Tripodi A, Primignani M, Chantarangkul V, Dell'Era A, Clerici M, de FR, Colombo M, Mannucci PM: An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology. 2009, 137: 2105-2111. 10.1053/j.gastro.2009.08.045.CrossRefPubMed Tripodi A, Primignani M, Chantarangkul V, Dell'Era A, Clerici M, de FR, Colombo M, Mannucci PM: An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology. 2009, 137: 2105-2111. 10.1053/j.gastro.2009.08.045.CrossRefPubMed
21.
go back to reference Sugita C, Yamashita A, Moriguchi-Goto S, Furukoji E, Takahashi M, Harada A, Soeda T, Kitazawa T, Hattori K, Tamura S, Asada Y: Factor VIII contributes to platelet-fibrin thrombus formation via thrombin generation under low shear conditions. Thromb Res. 2009, 124: 601-607. 10.1016/j.thromres.2009.06.035.CrossRefPubMed Sugita C, Yamashita A, Moriguchi-Goto S, Furukoji E, Takahashi M, Harada A, Soeda T, Kitazawa T, Hattori K, Tamura S, Asada Y: Factor VIII contributes to platelet-fibrin thrombus formation via thrombin generation under low shear conditions. Thromb Res. 2009, 124: 601-607. 10.1016/j.thromres.2009.06.035.CrossRefPubMed
Metadata
Title
Severe gastric variceal haemorrhage due to splenic artery thrombosis and consecutive arterial bypass
Authors
Klaus T von Trotha
Marcel Binnebösel
Son Truong
Florian F Behrendt
Hermann E Wasmuth
Ulf P Neumann
Marc Jansen
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Surgery / Issue 1/2011
Electronic ISSN: 1471-2482
DOI
https://doi.org/10.1186/1471-2482-11-14

Other articles of this Issue 1/2011

BMC Surgery 1/2011 Go to the issue