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Immunologic Research
Published in: Immunologic Research 1-3/2007

01-07-2007

Severe combined immunodeficiency: new advances in diagnosis and treatment

Author: Jennifer M. Puck

Published in: Immunologic Research | Issue 1-3/2007

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Abstract

Severe combined immunodeficiency (SCID) is a condition characterized by lack of cellular and humoral immunity. Uniformly fatal before 1968, SCID was first cured by allogeneic bone marrow transplantation (BMT). Despite improvements in BMT, particularly for cases in which there is no matched related donor, difficulties in SCID treatment persist. Because of incomplete reconstitution and transplant-related complications, gene therapy has been pioneered in SCID with success, but also adverse events in the form of leukemic proliferations related to retroviral insertional mutagenesis. Infectious complications are a major limitation to effective treatment. Early diagnosis of SCID in the pre-symptomatic period could be achieved by population-based newborn screening.
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Metadata
Title
Severe combined immunodeficiency: new advances in diagnosis and treatment
Author
Jennifer M. Puck
Publication date
01-07-2007
Publisher
Humana Press Inc
Published in
Immunologic Research / Issue 1-3/2007
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-007-0029-8

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