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International Journal of Hematology
Published in: International Journal of Hematology 4/2010

01-05-2010 | Case Report

Severe autoimmune neutropenia associated with acute autoimmune hepatitis

Authors: Ahmad M. Wehbe, Birgir Johannsson, Thomas J. Raife, Michelle Bleile, Adam Bell, Brian R. Curtis, Thorvardur R. Halfdanarson

Published in: International Journal of Hematology | Issue 4/2010

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Abstract

A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm3), normal hemoglobin and mild thrombocytopenia (115000/mm3). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient’s blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.
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Metadata
Title
Severe autoimmune neutropenia associated with acute autoimmune hepatitis
Authors
Ahmad M. Wehbe
Birgir Johannsson
Thomas J. Raife
Michelle Bleile
Adam Bell
Brian R. Curtis
Thorvardur R. Halfdanarson
Publication date
01-05-2010
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 4/2010
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-010-0557-1

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