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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 6/2016

01-06-2016 | Gynecologic Endocrinology and Reproductive Medicine

Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis

Authors: Shi Shi Lv, Ji Ying Wang, Xiao Qian Wang, Yan Wang, Yong Xu

Published in: Archives of Gynecology and Obstetrics | Issue 6/2016

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Abstract

Objective

To assess the correlation between serum 25-hydroxy vitamin D [25(OH)D] status and outcomes of in vitro fertilization (IVF) in infertile women through review systematically.

Methods

We used Embase, Pubmed, and Cochrane database to identify all studies that assessed the correlation between serum vitamin D levels and IVF outcomes in infertile women up until 30 June 2015, with the restricted language of English. We included studies that compared IVF outcomes between infertile women vitamin D <20 ng/ml and vitamin D ≥20 ng/ml. The results were summarized using Stata 12.0 software. For studies reported dichotomous outcomes (clinical pregnancy rate and live birth rate), we pooled the relative risks ratios (RRs) and 95 % confidence intervals (CIs) in a random effects model.

Results

Our search resulted in the retrieval and screening of 134 studies. Of those, five studies were included in our meta-analysis. The risk for lower clinical pregnancy rate was not significantly increased in the deficient group (RR 0.88, 95 % CI 0.69–1.11). Lower vitamin D status was associated with lower live birth rate (RR 0.76, 95 % CI 0.61–0.93).

Conclusion

There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization. On the other hand, deficient vitamin D level was related to lower live birth rate.
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Metadata
Title
Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis
Authors
Shi Shi Lv
Ji Ying Wang
Xiao Qian Wang
Yan Wang
Yong Xu
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 6/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-016-4058-1

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