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Environmental Health and Preventive Medicine
Published in: Environmental Health and Preventive Medicine 5/2016

01-09-2016 | Regular Article

Serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios as an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men

Authors: Yuji Shimizu, Hiroyuki Yoshimine, Mako Nagayoshi, Koichiro Kadota, Kensuke Takahashi, Kiyohiro Izumino, Kenichiro Inoue, Takahiro Maeda

Published in: Environmental Health and Preventive Medicine | Issue 5/2016

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Abstract

Objectives

Several studies have reported the association between sleep apnea syndrome and insulin resistance. Being overweight is known risk factor both for sleep apnea syndrome and insulin resistance. However, no studies have reported on the association between serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios (a marker of insulin resistance) and sleep apnea syndrome accounting for body mass index (BMI) status.

Methods

Subjects for the present cross-sectional study consisted of 1,528 men aged 30–69 years undergoing pulse oximetry at a sleep disorders clinic for sleep apnea syndrome. Sleep apnea syndrome was diagnosed as a 3 % oxygen desaturation index (ODI) of ≥15 events/h.

Results

Among study participants, 241 men were diagnosed with sleep apnea syndrome. Independent of classical cardiovascular risk factors, TG-HDL was significantly positively associated with sleep apnea syndrome in participants with a BMI <25 kg/m2, but not in participants with a BMI ≥25 kg/m2. The multivariable adjusted odds ratio (OR) and 95 % confidence interval (95 % CI) of sleep apnea syndrome per Log TG-HDL was 2.03 (95 % CI: 1.36–3.03) for a BMI <25 kg/m2 and 1.23 (95 % CI: 0.89–1.70) for a BMI ≥25 kg/m2.

Conclusions

An independent positive association between TG-HDL levels and risk of sleep apnea syndrome was observed in participants with a BMI of <25 kg/m2, but not in participants with a BMI ≥25 kg/m2. TG-HDL levels could be an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men.
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Metadata
Title
Serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios as an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men
Authors
Yuji Shimizu
Hiroyuki Yoshimine
Mako Nagayoshi
Koichiro Kadota
Kensuke Takahashi
Kiyohiro Izumino
Kenichiro Inoue
Takahiro Maeda
Publication date
01-09-2016
Publisher
Springer Japan
Published in
Environmental Health and Preventive Medicine / Issue 5/2016
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1007/s12199-016-0532-4

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