Top

Neurological Sciences

Published in:

01-12-2018 | Original Article

Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjects

Authors: Mustafa Ceylan, Ahmet Yalcin, Omer Faruk Bayraktutan, Esra Laloglu

Published in: Neurological Sciences | Issue 12/2018

Abstract

Purpose

Epileptic seizure is the result of uncontrollable neural excitation in the brain. The C-type natriuretic peptide is a member of natriuretic peptide hormone family and is synthesized by brain and blood vessels in CNS. NT-pro CNP is an amino-terminal fragment of C-type natriuretic peptide and is more stable compared to its predecessor. In this study, we aimed to evaluate the role of NT-pro CNP in psychogenic non-epileptic seizures, epileptic seizures, and normal subjects.

Methods

Thirty-three patients with epilepsy and 43 patients with psychogenic non-epileptic seizures were enrolled in this study. The control group consisted of 28 healthy subjects. Post-ictal serum levels of NT-pro CNP were acquired from all participants. Statistically significant differences between patient groups and controls regarding serum levels of NT-pro CNP were sought.

Results

NT-pro CNP levels were significantly lower in the epilepsy group than the psychogenic non-epileptic seizure group and control group with no significant difference between the psychogenic non-epileptic seizure and control group (p < 0.05).

Conclusion

Post-ictal serum NT-pro CNP levels were lower in epileptic seizures compared to psychogenic non-epileptic seizures as well as healthy controls. We think that such a difference is associated with C-type natriuretic peptide-related neural mechanisms such as altered microcirculation, increased brain-blood barrier permeability, and synaptic stabilization.

Bodde NMG, Brooks JL, Baker GA, Boon PAJM, Hendriksen JGM, Mulder OG, Aldenkamp AP (2009) Psychogenic non-epileptic seizures--definition, etiology, treatment and prognostic issues: a critical review. Seizure 18:543–553CrossRefPubMed

Noachtar S, Peters AS (2009) Semiology of epileptic seizures: a critical review. Epilepsy Behav 15:2–9CrossRefPubMed

Alsaadi TM, Thieman C, Shatzel A et al (2004) Video-EEG telemetry can be a crucial tool for neurologists experienced in epilepsy when diagnosing seizure disorders. Seizure 13:32–34CrossRefPubMed

Dobesberger J, Walser G, Unterberger I, Seppi K, Kuchukhidze G, Larch J, Bauer G, Bodner T, Falkenstetter T, Ortler M, Luef G, Trinka E (2011) Video-EEG monitoring: safety and adverse events in 507 consecutive patients. Epilepsia 52:443–452CrossRefPubMed

Lukasiuk K, Becker AJ (2014) Molecular biomarkers of epileptogenesis. Neurotherapeutics 11:319–323CrossRefPubMedCentralPubMed

Dash PK, Zhao J, Hergenroeder G, Moore AN (2010) Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury. Neurotherapeutics 7:100–114CrossRefPubMedCentralPubMed

Glushakova OY, Jeromin A, Martinez J, Johnson D, Denslow N, Streeter J, Hayes RL, Mondello S (2012) Cerebrospinal fluid protein biomarker panel for assessment of neurotoxicity induced by kainic acid in rats. Toxicol Sci 130:158–167CrossRefPubMed

Scotland RS, Ahluwalia A, Hobbs AJ (2005) C-type natriuretic peptide in vascular physiology and disease. Pharmacol Ther 105:85–93CrossRefPubMed

Stingo AJ, Clavell AL, Heublein DM et al (1992) Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Phys 263:1318–1321

10.

Nishikimi T, Kuwahara K, Nakao K (2011) Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides. J Cardiol 57:131–140CrossRefPubMed

11.

Komarek M, Bernheim A, Schindler R, Steden R, Kiowski W, Rocca HPBL (2004) Vascular effects of natriuretic peptides in healthy men. J Cardiovasc Pharmacol Ther 9:263–270CrossRefPubMed

12.

Brandt RR, Mattingly MT, Clavell AL, Barclay PL, Burnett JC (1997) Neutral endopeptidase regulates C-type natriuretic peptide metabolism but does not potentiate its bioactivity in vivo. Hypertension 30:184–190CrossRefPubMed

13.

Schouten BJ, Prickett TC, Hooper AA et al (2011) Central and peripheral forms of C-type natriuretic peptide (CNP): evidence for differential regulation in plasma and cerebrospinal fluid. Peptides 32:797–804CrossRefPubMed

14.

Prickett TCR, Yandle TG, Nicholls MG, Espiner EA, Richards AM (2001) Identification of amino-terminal pro-C-type natriuretic peptide in human plasma. Biochem Biophys Res Commun 286:513–517CrossRefPubMed

15.

Chen DK, So YT, Fisher RS (2005) Use of serum prolactin in diagnosing epileptic seizures: report of the therapeutics and technology assessment Subcommittee of the American Academy of Neurology. Neurology 65:668–675CrossRefPubMed

16.

Chang CC, Lui CC, Lee CC et al (2012) Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy. BMC Neurol 14:12–15

17.

Anand-Srivastava MB (2005 Jun) Natriuretic peptide receptor-C signaling and regulation. Peptides 26(6):1044–1059 Review

18.

Hu P, Zhao XQ, Wang J, Kong HB, Hu B, Lu L, Qin YH (2014) Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy. J Renin-Angiotensin-Aldosterone Syst 15:458–465CrossRefPubMed

19.

Peebles KC, Richards AM, Celi L, Mc Grattan K, Murrell CJ, Ainslie PN (2008) Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases. J Appl Physiol 105:1060–1068CrossRefPubMed

20.

Prickett TC, Charles CJ, Yandle TG, Richards AM, Espiner EA (2009) Skeletal contributions to plasma CNP forms: evidence from regional sampling in growing lambs. Peptides 30:2343–2347CrossRefPubMed

21.

Van Paesschen W (2004) Ictal SPECT. Epilepsia 45:35–40CrossRefPubMed

22.

Boscolo Galazzo I, Storti SF, Del Felice A et al (2015) Patient-specific detection of cerebral blood flow alterations as assessed by arterial spin labeling in drug-resistant epileptic patients. PLoS One 6:10

23.

Attwell D, Buchan AM, Charpak S, Lauritzen M, MacVicar BA, Newman EA (2010) Glial and neuronal control of brain blood flow. Nature 468:232–243CrossRefPubMedCentralPubMed

24.

Bohara M, Kambe Y, Nagayama T, Tokimura H, Arita K, Miyata A (2014) C-type natriuretic peptide modulates permeability of the blood-brain barrier. J Cereb Blood Flow Metab 34:589–596CrossRefPubMedCentralPubMed

25.

Muller D, Hida B, Guidone G et al (2009) Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis. Endocrinology 150:5520–5529CrossRefPubMed

26.

Decker JM, Wojtowicz AM, Bartsch JC et al (2010) C-type natriuretic peptide modulates bidirectional plasticity in hippocampal area CA1 in vitro. Neuroscience 169:8–22CrossRefPubMed

27.

Zhao Z, Ma L (2009) Regulation of axonal development by natriuretic peptide hormones. Proc Natl Acad Sci U S A 106:18016–18021CrossRefPubMedCentralPubMed

Title: Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjects
Authors: Mustafa Ceylan
Ahmet Yalcin
Omer Faruk Bayraktutan
Esra Laloglu
Publication date: 01-12-2018
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 12/2018
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-018-3562-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serum NT-pro CNP levels in epileptic seizure, psychogenic non-epileptic seizure, and healthy subjects

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 12/2018

Parkinsonism and multiple sclerosis, what is behind?

Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms

Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to epilepsy

Performance of the COMPASS-31 questionnaire with regard to autonomic nervous system testing results and medication use: a prospective study in a real-life setting

A novel homozygous GALC variant has been associated with Krabbe disease in a consanguineous family

The efficacy and safety of calcitonin gene-related peptide monoclonal antibody for episodic migraine: a meta-analysis