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01-02-2011 | Original Article

Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer

Authors: Hiroyuki Yamaguchi, Hiroshi Soda, Yoichi Nakamura, Mineyo Takasu, Nanae Tomonaga, Hirofumi Nakano, Seiji Doi, Katsumi Nakatomi, Seiji Nagashima, Hiroshi Takatani, Minoru Fukuda, Tomayoshi Hayashi, Kazuhiro Tsukamoto, Shigeru Kohno

Published in: Cancer Chemotherapy and Pharmacology | Issue 2/2011

Abstract

Purpose

Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that has dramatic effects in selective patients with non-small cell lung cancer (NSCLC). A simple non-invasive method for predicting the efficacy of gefitinib is preferable in clinical settings. In this study, we evaluated prospectively whether surfactant protein-A (SP-A) and -D (SP-D) may be new conventional predictors of the efficacy of gefitinib treatment.

Methods

We measured serum SP-A and SP-D levels on days 0 and 29 in 40 patients with advanced NSCLC treated with 250 mg gefitinib daily. Eligibility criteria included performance status ≤3, age ≤80 years, and stage IIIB–IV disease. In addition, EGFR mutations were analyzed in 24 patients.

Results

Multivariate analysis showed that favorable progression-free survival (PFS) after gefitinib treatment was associated with adenocarcinoma and high serum SP-D levels before treatment. EGFR mutation analysis of 24 patients showed that 16 patients had exon 19 deletion and/or exon 21 point mutations. EGFR mutations were significantly correlated with response to gefitinib and serum SP-D levels before treatment was significantly high in patients with the EGFR mutations. Serum SP-A levels were not associated with PFS.

Conclusions

The present study showed that measurement of serum SP-D levels before treatment in patients with NSCLC may be a new surrogate marker for predicting the response to gefitinib.

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Title: Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer
Authors: Hiroyuki Yamaguchi
Hiroshi Soda
Yoichi Nakamura
Mineyo Takasu
Nanae Tomonaga
Hirofumi Nakano
Seiji Doi
Katsumi Nakatomi
Seiji Nagashima
Hiroshi Takatani
Minoru Fukuda
Tomayoshi Hayashi
Kazuhiro Tsukamoto
Shigeru Kohno
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: Cancer Chemotherapy and Pharmacology / Issue 2/2011
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-010-1325-x

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