Serum chemerin and insulin sensitivity alterations due to exercise training below and above lactate thresholds in streptozocin-induced diabetic rats

The aim of this study was to investigate serum chemerin and insulin sensitivity alterations due to exercise training below and above lactate thresholds in streptozocin-induced diabetic rats. Twenty-four rats (190 ± 14 g) were randomly assigned to three groups of control (CON), above lactate thresholds (ALT) and below lactate thresholds (BLT) (n = 8). Then after induction of diabetes, BLT and ALT performed an 8-week exercise program on treadmill running (15 and 27 m/min, respectively) at 0° slope, 1 h/day, and 5 days/week. SPSS version 16 was used for data analysis. The findings showed that, BLT serum chemerin decreased −27 % compared to CON that was statistically significant (p = 0.042), fasting Glucose level of ALT was significantly decreased 19 % compared to CON after 8-week training protocol (p = 0.02). Also 24 % significant reduction was observed in BLT in comparison to CON (p = 0.005). Insulin sensitivity of BLT and ALT improved 7 and 5 %, respectively, compared to CON and both were not significant. Also, positive correlationship was observed between fasting plasma glucose and serum chemerin but it was not significant statistically. Negative correlationship was seen between plasma insulin level and chemerin concentrations and it was not significant too. Compared with CON, BLT weight was significantly reduced 12 % (p = 0.012). Also 9 % weight loss was observed in ALT due to 8-week exercise training which was not statistically significant (p = 0.058). In summary, 8-week exercise training below lactate thresholds may reduce serum chemerin and improve fasting glucose levels.