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01-02-2012 | Review Article

Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport

Authors: Florian Lang, Volker Vallon

Published in: Clinical and Experimental Nephrology | Issue 1/2012

Abstract

Serum- and glucocorticoid inducible-kinase 1 (SGK1) is an early gene transcriptionally upregulated by cell stress such as cell shrinkage and hypoxia and several hormones including gluco- and mineralocorticoids. It is activated by insulin and growth factors. SGK1 is a powerful regulator of a wide variety of channels and transporters. The present review describes the role of SGK1 in the regulation of potassium (K⁺) channels, K⁺ transporters and K⁺ homeostasis. SGK1-regulated K⁺ channels include renal outer medullary K+ channel, Kv1.3, Kv1.5, KCNE1/KCNQ1, KCNQ4 and, via regulation of calcium (Ca²⁺) entry, Ca²⁺-sensitive K⁺ channels. SGK1-sensitive transporters include sodium–potassium-chloride cotransporter 2 and sodium/potassium-adenosine triphosphatase. SGK1-dependent regulation of K⁺ channels and K⁺ transport contributes to the stimulation of renal K⁺ excretion following high K⁺ intake, to insulin-induced cellular K⁺ uptake and hypokalemia, to inhibition of insulin release by glucocorticoids, to stimulation of mast cell degranulation and gastric acid secretion, and to cardiac repolarization. Thus, SGK1 has a profound effect on K⁺ homeostasis and on a multitude of K⁺-sensitive cellular functions.

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Title: Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport
Authors: Florian Lang
Volker Vallon
Publication date: 01-02-2012
Publisher: Springer Japan
Published in: Clinical and Experimental Nephrology / Issue 1/2012
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-011-0488-z

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