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BMC Neurology
Published in: BMC Neurology 1/2016

Open Access 01-12-2016 | Research article

Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study

Authors: Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Fumitaro Miyatani, Masaki Kondo, Aiko Tamura, Takashi Kasai, Yoichi Ohshima, Tomokatsu Yoshida, Takahiko Tokuda, Ikuko Mizuta, Shigeto Mizuno, Kei Yamada, Kazuo Takeda, Sanae Matsumoto, Masanori Nakagawa, Toshiki Mizuno, Yoshiyuki Watanabe

Published in: BMC Neurology | Issue 1/2016

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Abstract

Background

Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definitive candidate causes have been identified. The present study evaluated whether certain serum parameters predict CD.

Methods

A total of 151 participants were assessed for CD using the Mini-Mental State Examination (MMSE), and 34 participants were identified as showing CD.

Results

Among CD predictive risk factors, Helicobacter pylori seropositivity was significantly predictive of CD risk, more so than classical risk factors, including white matter lesions and arterial stiffness [adjusted odds ratio (OR) = 4.786, 95% confidence interval (CI) = 1.710–13.39]. A multivariate analysis indicated that the albumin to globulin (A/G) ratio was the only factor that significantly lowered CD risk (OR = 0.092, 95% CI = 0.010–0.887). A/G ratio also was positively correlated with MMSE scores and negatively correlated with disruption of homeostatic factors (i.e., non-high-density lipoprotein, hemoglobin A1c, and high-sensitive C-reactive protein).

Conclusions

The current study results suggest that the A/G ratio is related to cognitive decline and may reflect homeostatic alterations.
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Metadata
Title
Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study
Authors
Teruhide Koyama
Nagato Kuriyama
Etsuko Ozaki
Daisuke Matsui
Isao Watanabe
Fumitaro Miyatani
Masaki Kondo
Aiko Tamura
Takashi Kasai
Yoichi Ohshima
Tomokatsu Yoshida
Takahiko Tokuda
Ikuko Mizuta
Shigeto Mizuno
Kei Yamada
Kazuo Takeda
Sanae Matsumoto
Masanori Nakagawa
Toshiki Mizuno
Yoshiyuki Watanabe
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2016
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-016-0776-z

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