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01-01-2009 | Biological Psychiatry - Original Article

Serotonin-induced decrease of intracellular Ca²⁺ release in platelets of bulimic patients normalizes during treatment

Authors: Lars Wöckel, Florian Daniel Zepf, Sabrina Koch, Anikó-Eva Meyer-Keitel, Martin H. Schmidt

Published in: Journal of Neural Transmission | Issue 1/2009

Abstract

Numerous symptoms related to eating disorders have been shown to be influenced by serotonergic (5-HT) functioning, with the 5-HT_2A receptor subtype being one of the most relevant involved in the pathophysiology of bulimia nervosa (BN). In line with this, Ca²⁺ mobilization as mediated by 5-HT₂ receptors in platelets was shown to serve as a peripheral model for central nervous 5-HT functioning. Here, the 5-HT-induced intracellular Ca²⁺ mobilization in platelets was measured in 13 female normal weight bulimic patients (14–18 years) upon admission and at the end of inpatient treatment. Findings were compared to 21 age-matched healthy female adolescents. 5-HT-induced Ca²⁺ release was significantly decreased in bulimic patients upon admission and normalized during inpatient treatment. Antidepressive medication caused a significant improvement. The data provide further evidence that altered 5-HT₂ receptor functioning is involved in the pathophysiological underpinnings in BN.

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Title: Serotonin-induced decrease of intracellular Ca2+ release in platelets of bulimic patients normalizes during treatment
Authors: Lars Wöckel
Florian Daniel Zepf
Sabrina Koch
Anikó-Eva Meyer-Keitel
Martin H. Schmidt
Publication date: 01-01-2009
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 1/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0163-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serotonin-induced decrease of intracellular Ca²⁺ release in platelets of bulimic patients normalizes during treatment

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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