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Open Access 07-02-2024 | Review Article

Serendipity in oto-rhino-laryngology

Authors: Pek van Andel, Louw Feenstra, Henk G. Schmidt

Published in: European Archives of Oto-Rhino-Laryngology

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Abstract

Introduction

Serendipitous findings are findings that were initially unsought but nevertheless contribute to the development of the discipline. This article reviews eight serendipitous findings in oto-rhino-laryngology important to its advancement.

Method

The following serendipitous findings are discussed: the accidental discovery of the laryngeal mirror and indirect laryngoscopy by Garcia (1854), the invention of direct oesophagoscopy by Kußmaul (circa 1868), Czermák’s (1863) development of diaphanoscopy, the unintentional emergence of bronchography from a clinical error made by Weingartner (1914), adenotomy by Meyer (1869), the discovery of the causes of unbalance related to the vestibular nerve by Flourens (1830), Bárány’s (1914) finding that the semi-circular canal reflex is involved in equilibrium, and the relationship between gastroesophageal reflux and middle-ear infections by Poelmans and Feenstra (2002).

Discussion

Based on these case studies we conclude that serendipity, defined as the art of making an initially unsought find, does not always appear out of nowhere. Often the researcher is already wrestling with a problem for which the serendipitous finding provides a solution. Sometimes the serendipitous finding enables the application of a known solution to a new problem. And sometimes a serendipitous finding is not recognized as such or considered unimportant. Since observations tend to be theory-loaded, having appropriate background knowledge is a conditio sine qua non to elaborate an unanticipated observation.
Footnotes
1
Les observations médicales nouvelles se font généralement par hasard (…) L’initiative du médecin consiste à voir et à ne pas laisser échapper le fait que le hasard lui a offert, et son mérite se réduit à l’observer avec exactitude (…) Il n’y a rien d’accidentel, et ce qui pour nous est accident n’est qu’un fait inconnu qui peut devenir, si on l’explique, l’occasion d’une découverte plus ou moins importante [1].
 
2
(…) (par hasard diriez-vous peut-être, mais souvenez-vous que dans les sciences de l’observation le hasard ne favorise que des esprits préparés). Cited in [2].
 
3
A highly readable account of serendipitous discoveries in the field of ophthalmology already exists [4].
 
4
The classical example of serendipity in response to a perceived problem is of course the discovery of penicillin. Alexander Fleming was already looking for what we now call an antibiotic and published about one: lysozyme. Then he accidentally stumbled over an even more effective substance.
 
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Metadata
Title
Serendipity in oto-rhino-laryngology
Authors
Pek van Andel
Louw Feenstra
Henk G. Schmidt
Publication date
07-02-2024
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-024-08475-6