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01-03-2011 | Brief Report

Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5

Authors: Andreas Sauerbrei, Nadine Wiesener, Roland Zell, Peter Wutzler

Published in: Archives of Virology | Issue 3/2011

Abstract

Eighty-six varicella-zoster virus (VZV) strains of clades 1, 3 and 5, isolated from varicella and zoster patients in Germany, were analyzed by sequencing the glycoprotein E gene. Four novel non-synonymous and 10 novel synonymous mutations were detected. Of these, two synonymous (C513T, C885T) and two non-synonymous mutations (T485G, C524T) were located within the coding regions of e1 and c1. The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5.

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Title: Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5
Authors: Andreas Sauerbrei
Nadine Wiesener
Roland Zell
Peter Wutzler
Publication date: 01-03-2011
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 3/2011
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-010-0864-0

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