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Journal of Inflammation
Published in: Journal of Inflammation 1/2020

Open Access 01-12-2020 | Septicemia | Research

Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women

Authors: Sofie Jacobson, Peter Larsson, Anna-Maja Åberg, Göran Johansson, Ola Winsö, Stefan Söderberg

Published in: Journal of Inflammation | Issue 1/2020

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Abstract

Background

Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL deficiency leads to increased susceptibility to infections or not. The aim of this study was to determine if low levels of mannose-binding lectin (MBL) predict sepsis development, sepsis severity and outcome from severe sepsis or septic shock.

Method

Patients aged 18 years or more with documented sepsis within 24 h after admission to the intensive care unit were included if they had participated in a health survey and donated blood samples prior to the sepsis event. A subset of these patients had stored plasma also from the acute phase. Two matched referents free of known sepsis were selected for each case. Plasma levels MBL were determined in stored samples from health surveys (baseline) and from ICU admission (acute phase). The association between MBL and sepsis, sepsis severity and in-hospital mortality were determined with 1300 ng/mL as cut-off for low levels.

Results

We identified 148 patients (61.5% women) with a first-time sepsis event 6.5 years (median with IQR 7.7) after participation in a health survey, of which 122 also had samples from the acute septic phase. Both high MBL levels in the acute phase (odds ratio [95% confidence interval]) (2.84 [1.20–6.26]), and an increase in MBL levels from baseline to the acute phase (3.76 [1.21–11.72]) were associated with increased risk for in-hospital death in women, but not in men (0.47 [0.11–2.06]). Baseline MBL levels did not predict future sepsis, sepsis severity or in-hospital mortality.

Conclusions

An increase from baseline to the acute phase as well as high levels in the acute phase associated with an unfavourable outcome in women.
Appendix
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Metadata
Title
Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women
Authors
Sofie Jacobson
Peter Larsson
Anna-Maja Åberg
Göran Johansson
Ola Winsö
Stefan Söderberg
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue 1/2020
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/s12950-020-00257-1

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